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- Triterpenes from Maytenus macrocarpa and evaluation of their anti-HIV activity
- Univ Salerno
- Universidade Estadual Paulista (UNESP)
- Univ London London Hosp
- A set of pentacyclic triterpenes has been isolated from the bark of Maytenus macrocarpa (Celastraceae). It includes two new olean-12-ene derivatives, namely 3 beta, 22(alpha-dihydroxy-olean-12-en-30-oic acid (1) and 22 alpha-hydroxy-olean-12-en-3-oxo-30-oic acid (2), and the new urs-12-ene derivative 3-(E)-coumaroyluvaol (7), along with 10 known compounds possessing olean-12ene, urs-12-ene, lupane and friedelane skeletons. The structures have been elucidated by extensive spectroscopic methods including ID- and 2D-NMR experiments, as well as ESI-MS analysis. All isolated compounds were tested for anti-HIV activity in C8166 cells infected with HIV-1(MN), the most active compound was 22(alpha-hydroxy-12-en-3-oxo-29-oic acid (triterpenonic acid A, 4), with an EC50 value of I mu g/mL and a selectivity index of 35.
- Natural Product Communications. Westerville: Natural Products Inc., v. 1, n. 12, p. 1073-1078, 2006.
- Natural Products Inc
- Maytenus macrocarpa
- pentacyclic triterpenes
- anti-HIV activity
- Acesso restrito
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