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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/37465
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dc.contributor.authorPiacente, Sonia-
dc.contributor.authorDos Santos, Lourdes Campaner-
dc.contributor.authorMahmood, Naheed-
dc.contributor.authorPizza, Cosimo-
dc.date.accessioned2014-05-20T15:27:30Z-
dc.date.accessioned2016-10-25T18:02:20Z-
dc.date.available2014-05-20T15:27:30Z-
dc.date.available2016-10-25T18:02:20Z-
dc.date.issued2006-01-01-
dc.identifier.citationNatural Product Communications. Westerville: Natural Products Inc., v. 1, n. 12, p. 1073-1078, 2006.-
dc.identifier.issn1934-578X-
dc.identifier.urihttp://hdl.handle.net/11449/37465-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/37465-
dc.description.abstractA set of pentacyclic triterpenes has been isolated from the bark of Maytenus macrocarpa (Celastraceae). It includes two new olean-12-ene derivatives, namely 3 beta, 22(alpha-dihydroxy-olean-12-en-30-oic acid (1) and 22 alpha-hydroxy-olean-12-en-3-oxo-30-oic acid (2), and the new urs-12-ene derivative 3-(E)-coumaroyluvaol (7), along with 10 known compounds possessing olean-12ene, urs-12-ene, lupane and friedelane skeletons. The structures have been elucidated by extensive spectroscopic methods including ID- and 2D-NMR experiments, as well as ESI-MS analysis. All isolated compounds were tested for anti-HIV activity in C8166 cells infected with HIV-1(MN), the most active compound was 22(alpha-hydroxy-12-en-3-oxo-29-oic acid (triterpenonic acid A, 4), with an EC50 value of I mu g/mL and a selectivity index of 35.en
dc.format.extent1073-1078-
dc.language.isoeng-
dc.publisherNatural Products Inc-
dc.sourceWeb of Science-
dc.subjectMaytenus macrocarpapt
dc.subjectCelastraceaept
dc.subjectpentacyclic triterpenespt
dc.subjectanti-HIV activitypt
dc.titleTriterpenes from Maytenus macrocarpa and evaluation of their anti-HIV activityen
dc.typeoutro-
dc.contributor.institutionUniv Salerno-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniv London London Hosp-
dc.description.affiliationUniv Salerno, Dipartimento Sci Farmaceut, I-84084 Salerno, Italy-
dc.description.affiliationUNESP, Inst Quim, BR-14801970 Araraquara, SP, Brazil-
dc.description.affiliationUniv London London Hosp, Acad Virol, Retroscreen Ltd, London E1 2AD, England-
dc.description.affiliationUnespUNESP, Inst Quim, BR-14801970 Araraquara, SP, Brazil-
dc.identifier.wosWOS:000249007000003-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofNatural Product Communications-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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