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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/37483
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dc.contributor.authorSilva, Renata N.-
dc.contributor.authorRibeiro, Daniel A.-
dc.contributor.authorSalvadori, Daisy Maria Favero-
dc.contributor.authorMarques, Mariângela Esther Alencar-
dc.date.accessioned2014-05-20T15:27:31Z-
dc.date.accessioned2016-10-25T18:02:22Z-
dc.date.available2014-05-20T15:27:31Z-
dc.date.available2016-10-25T18:02:22Z-
dc.date.issued2007-09-01-
dc.identifierhttp://dx.doi.org/10.1016/j.etp.2007.02.010-
dc.identifier.citationExperimental and Toxicologic Pathology. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 59, n. 1, p. 61-68, 2007.-
dc.identifier.issn0940-2993-
dc.identifier.urihttp://hdl.handle.net/11449/37483-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/37483-
dc.description.abstractTaking into consideration that glutatione S-transferase (GST) and cellular proliferation play a crucial role during carcinogenesis, the goal of this study was to investigate the expression of placental GST, called GST-P, and proliferating cellular nuclear antigen (PCNA) by means of immunohistochemistry during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide (4NQO). This is a useful model for studying oral squamous cell carcinoma phase by phase. Male Wistar rats were distributed into three groups of 10 animals each and treated with 50 ppm 4NQO solution by drinking water for 4, 12 or 20 weeks. Ten animals were used as negative control. GST-P positive foci were detected in non-neoplastic oral cells at 4 weeks of 4NQO administration. In the same way, GST-P positive cells were detected in pre-neoplastic lesions and squamous cell carcinomas induced after 12 and 20 weeks-treatment, respectively. None of the control animals expressed GST-P positive cells. Regarding cellular proliferation, PCNA positive nuclei were higher at 12 and 20 weeks following 4NQO exposure (p < 0.05) when compared to negative control. These results suggest that the expression of GST-P is correlated with cellular proliferation, in which GST-P is associated with risk and progression of oral cancer, whereas PCNA is closely involved during neoplastic conversion. (c) 2007 Published by Elsevier GmbH.en
dc.format.extent61-68-
dc.language.isoeng-
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.subjectplacental glutathione S-transferasept
dc.subjectRat tongue mucosapt
dc.subjectOral squamous cell carcinomapt
dc.subject4-nitroquinoline 1-oxidept
dc.titlePlacental glutathione S-transferase correlates with cellular proliferation during rat tonguie carcinogenesis induced by 4-nitroquinoline 1-oxideen
dc.typeoutro-
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv Fed São Paulo, Dept Hlth Sci, BR-11060001 Santos, SP, Brazil-
dc.description.affiliationUniv Nacl Estadual São Paulo, São Paulo State Univ, Botucatu Med Sch, Dept Pathol, São Paulo, Brazil-
dc.description.affiliationUnespUniv Nacl Estadual São Paulo, São Paulo State Univ, Botucatu Med Sch, Dept Pathol, São Paulo, Brazil-
dc.identifier.doi10.1016/j.etp.2007.02.010-
dc.identifier.wosWOS:000249608100008-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofExperimental and Toxicologic Pathology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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