Please use this identifier to cite or link to this item:
http://acervodigital.unesp.br/handle/11449/37827
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lopes Correa, Ana Paula Ferreira | - |
dc.contributor.author | Silva Dossi, Ana Claudia | - |
dc.contributor.author | Vasconcelos, Rosemeri de Oliveira | - |
dc.contributor.author | Munari, Danisio Prado | - |
dc.contributor.author | Felix de Lima, Valeria Marcal | - |
dc.date.accessioned | 2014-05-20T15:27:54Z | - |
dc.date.accessioned | 2016-10-25T18:02:52Z | - |
dc.date.available | 2014-05-20T15:27:54Z | - |
dc.date.available | 2016-10-25T18:02:52Z | - |
dc.date.issued | 2007-02-28 | - |
dc.identifier | http://dx.doi.org/10.1016/j.vetpar.2006.08.023 | - |
dc.identifier.citation | Veterinary Parasitology. Amsterdam: Elsevier B.V., v. 143, n. 3-4, p. 267-274, 2007. | - |
dc.identifier.issn | 0304-4017 | - |
dc.identifier.uri | http://hdl.handle.net/11449/37827 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/37827 | - |
dc.description.abstract | The aims of this study were to evaluate the immunomodulatory role of TGF-beta(1), 1L-10, and INF-gamma in spleen and liver extracts and supernatant cultures of white spleen cells from male symptomatic and asymptomatic dogs, naturally infected by Leishmania (Leishmania) chagasi. Thirty dogs from Aracatuba, São Paulo, Brazil, an endemic leishmaniosis area, were selected by positive ELISA serological reaction for Leishmania sp. and divided into two groups: asymptomatic (n=15) and symptomatic (n=15) consisting of animals with at least three characteristic signs (fever, dermatitis, lymphoadenopathy, onychogryphosis, weight loss, cachex a, locomotion problems, conjunctivitis, epistaxis, hepatosplenomegaly, edema, and apathy). After euthanasia, spleen and liver fragments were collected for ex vivo quantification of TGF-beta(1), IL-10, and INF-gamma. Naturally active in vitro produced TGF-beta(1) was also evaluated in spleen cell culture supernatant. Spleen and liver extract of asymptomatic dogs had higher mean TGF-beta(1) levels than symptomatic dogs. High concentrations of IL-10 were found in spleen, and mainly in liver extract of both groups. Higher INF-gamma concentrations were found in spleen extracts of symptomatic dogs, and in liver extracts of asymptomatic dogs. Extract of this cytokire was lower in spleen extract. Although INF-gamma is being produced in canine infection, mean levels of TGF-beta(1) and IL-10 from spleen and liver extracts were quantitatively much higher; suggesting that immune response in both asymptomatic and symptomatic dogs A as predominantly type Th2. (c) 2006 Elsevier B.V. All rights reserved. | en |
dc.format.extent | 267-274 | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.source | Web of Science | - |
dc.subject | ELISA | pt |
dc.subject | visceral leishmaniasis | pt |
dc.subject | spleen cell cultured | pt |
dc.subject | Th2 response | pt |
dc.subject | cytokines | pt |
dc.subject | zoonosis | pt |
dc.title | Evaluation of transformation growth factor beta(1), interleukin-10, and interferon-gamma in male symptomatic and asymptomatic dogs naturally infected by Leishmania (Leishmania) chagasi | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | UNESP, Fac Odontol, Dept Clin & Cururgia & Reprod, BR-16050680 Aracatuba, SP, Brazil | - |
dc.description.affiliation | UNESP, FCAV, Dept Ciências Exactas, Jaboticabal, SP, Brazil | - |
dc.description.affiliationUnesp | UNESP, Fac Odontol, Dept Clin & Cururgia & Reprod, BR-16050680 Aracatuba, SP, Brazil | - |
dc.description.affiliationUnesp | UNESP, FCAV, Dept Ciências Exactas, Jaboticabal, SP, Brazil | - |
dc.identifier.doi | 10.1016/j.vetpar.2006.08.023 | - |
dc.identifier.wos | WOS:000244440500010 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Veterinary Parasitology | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.