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dc.contributor.authorCarregaro, Adriano B.-
dc.contributor.authorLuna, Stélio Pacca Loureiro-
dc.contributor.authorMataqueiro, Maria Isabel-
dc.contributor.authorde Queiroz-Neto, Antonio-
dc.identifier.citationAmerican Journal of Veterinary Research. Schaumburg: Amer Veterinary Medical Assoc, v. 68, n. 3, p. 246-250, 2007.-
dc.description.abstractObjective-To investigate spontaneous locomotor activity (SLA) and antinociceptive effects of buprenorphine in horses.Animals-6 healthy adult horses.Procedures-Horses received each of 3 treatments (10 mL of saline [0.9% NaCl] solution, 5 mu g of buprenorphine/kg, or 10 mu g of buprenorphine/kg). Treatments were administered IV Order of treatments was randomized, and there was a 10-day interval between subsequent treatments. Spontaneous locomotor activity was investigated in a behavioral box by use of infrared photoelectric sensors connected to a computer, which detected movement of each horse. Antinociceptive effect was investigated by hoof-withdrawal reflex latency (HWRL) and skin-twitching reflex latency (STBL) after painful stimulation with a heat lamp.Results-Moderate excitement was observed in all horses from 5 to 10 minutes after the administration of both dosages of buprenorphine. The SLA increased significantly for 6 and 14 hours after IV administration of 5 and 10 mu g of buprenorphine/kg, respectively. Values for HWRL increased significantly only at 30 minutes after injection of 5 mu g of buprenorphine/kg, whereas STRL and HWRL each increased significantly from 1 to 6 hours (except at 2 and 4 hours) and 11 hours, respectively, after injection of 10 mu g of buprenorphine/kg.Conclusions and Clinical Relevance-IV injection of buprenorphine caused a dose-dependent increase in SLA, but only the dose of 10 mu g/kg induced analgesia on the basis of results for the experimental method used.en
dc.publisherAmer Veterinary Medical Assoc-
dc.sourceWeb of Science-
dc.titleEffects of buprenorphine on nociception and spontaneous locomotor activity in horsesen
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.description.affiliationUniv Estadual Paulista, Fac Ciências Agrarias & Vet, BR-14884900 Jaboticabal, Brazil-
dc.description.affiliationUniv Fed São Paulo, Sch Vet Med & Anim Sci, BR-18618000 Botucatu, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciências Agrarias & Vet, BR-14884900 Jaboticabal, Brazil-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofAmerican Journal of Veterinary Research-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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