You are in the accessibility menu

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/37859
Full metadata record
DC FieldValueLanguage
dc.contributor.authorDias, Mirela B.-
dc.contributor.authorNucci, Tatiane B.-
dc.contributor.authorMargatho, Lisandra O.-
dc.contributor.authorAntunes-Rodrigues, Jose-
dc.contributor.authorGargaglioni, Luciane H.-
dc.contributor.authorBranco, Luiz G. S.-
dc.date.accessioned2014-05-20T15:27:57Z-
dc.date.accessioned2016-10-25T18:02:55Z-
dc.date.available2014-05-20T15:27:57Z-
dc.date.available2016-10-25T18:02:55Z-
dc.date.issued2007-11-01-
dc.identifierhttp://dx.doi.org/10.1152/japplphysiol.00424.2007-
dc.identifier.citationJournal of Applied Physiology. Bethesda: Amer Physiological Soc, v. 103, n. 5, p. 1780-1788, 2007.-
dc.identifier.issn8750-7587-
dc.identifier.urihttp://hdl.handle.net/11449/37859-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/37859-
dc.description.abstractThere is evidence that serotonin [ 5- hydroxytryptamine ( 5- HT)] is involved in the physiological responses to hypercapnia. Serotonergic neurons represent the major cell type ( comprising 15 - 20% of the neurons) in raphe magnus nucleus ( RMg), which is a medullary raphe nucleus. In the present study, we tested the hypothesis 1) that RMg plays a role in the ventilatory and thermal responses to hypercapnia, and 2) that RMg serotonergic neurons are involved in these responses. To this end, we microinjected 1) ibotenic acid to promote nonspecific lesioning of neurons in the RMg, or 2) anti- SERT- SAP ( an immunotoxin that utilizes a monoclonal antibody to the third extracellular domain of the serotonin reuptake transporter) to specifically kill the serotonergic neurons in the RMg. Hypercapnia caused hyperventilation and hypothermia in all groups. RMg nonspecific lesions elicited a significant reduction of the ventilatory response to hypercapnia due to lower tidal volume ( V-T) and respiratory frequency. Rats submitted to specific killing of RMg serotonergic neurons showed no consistent difference in ventilation during air breathing but had a decreased ventilatory response to CO2 due to lower VT. The hypercapnia- induced hypothermia was not affected by specific or nonspecific lesions of RMg serotonergic neurons. These data suggest that RMg serotonergic neurons do not participate in the tonic maintenance of ventilation during air breathing but contribute to the ventilatory response to CO2. Ultimately, this nucleus may not be involved in the thermal responses CO2.en
dc.format.extent1780-1788-
dc.language.isoeng-
dc.publisherAmer Physiological Soc-
dc.sourceWeb of Science-
dc.subjecthypercapniapt
dc.subjectventilationpt
dc.subjectserotoninpt
dc.titleRaphe magnus nucleus is involved in ventilatory but not hypothermic response to CO2en
dc.typeoutro-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv São Paulo, Fac Odontol, Dept Physiol, Sch Dent, BR-14040904 Ribeirao Preto, Brazil-
dc.description.affiliationSão Paulo State Univ, UNESP, Dept Anim Morphol & Physiol, São Paulo, Brazil-
dc.description.affiliationUniv São Paulo, Sch Med, Dept Physiol, São Paulo, Brazil-
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Dept Anim Morphol & Physiol, São Paulo, Brazil-
dc.identifier.doi10.1152/japplphysiol.00424.2007-
dc.identifier.wosWOS:000250480400040-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Applied Physiology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.
 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.