Você está no menu de acessibilidade

Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/37868
Registro de metadados completo
Campo DCValorIdioma
dc.contributor.authorZanesco, A.-
dc.contributor.authorSpadariBratfisch, R. C.-
dc.contributor.authorBarker, L. A.-
dc.date.accessioned2014-05-20T15:27:57Z-
dc.date.accessioned2016-10-25T18:02:56Z-
dc.date.available2014-05-20T15:27:57Z-
dc.date.available2016-10-25T18:02:56Z-
dc.date.issued1997-02-01-
dc.identifierhttp://jpet.aspetjournals.org/content/280/2/677-
dc.identifier.citationJournal of Pharmacology and Experimental Therapeutics. Baltimore: Williams & Wilkins, v. 280, n. 2, p. 677-685, 1997.-
dc.identifier.issn0022-3565-
dc.identifier.urihttp://hdl.handle.net/11449/37868-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/37868-
dc.description.abstractRat isolated right atria obtained 1 wk after sinoaortic denervation were less sensitive to the chronotropic actions of beta-agonists than were tissues obtained from animals that underwent sham surgery or no surgery at all. The potencies, but not the maximal responses for two high efficacy agonists, norepinephrine and isoproterenol, were reduced about 3- to 4-fold. Sinoaortic denervation (SAD) caused about a 3-fold decrease in potency and about a 60% decrease in maximal response for a low efficacy agonist, prenalterol. The changes in the actions of these agonists occurred in the absence of any changes in the subtype of beta receptor mediating the chronotropic response. The results of analyses of the data for prenalterol showed that SAD caused a decrease in the operational efficacy of this agonist without any changes in its K-D value for beta-1 adrenoceptors. SAD had no effect on the responses of the tissue to blockade of uptake 1 and uptake 2, suggesting no compensatory changes in the removal processes caused the decreased potency. The results of radioligand binding assays showed that SAD caused a decrease in the maximal binding of I-125-cyanopindolol without altering its K-D. Also, the results of competition binding assays confirmed the lack of effect of SAD on the K-D for prenalterol. The SAD-induced changes in the actions of agonists acting at right atrial beta-1 receptors were caused by a down-regulation of beta-1 adrenoceptors, which probably occurred in response to SAD-induced increases in sympathetic tone.en
dc.format.extent677-685-
dc.language.isoeng-
dc.publisherWilliams & Wilkins-
dc.sourceWeb of Science-
dc.titleSino-aortic denervation causes right atrial beta adrenoceptor down-regulationen
dc.typeoutro-
dc.contributor.institutionLOUISIANA STATE UNIV-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionDEPT PHYSIOL & BIOPHYS-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationLOUISIANA STATE UNIV,MED CTR,DEPT PHARMACOL,SCH DENT,NEW ORLEANS,LA 70119-
dc.description.affiliationUNIV CAMPINAS,SAO PAULO,BRAZIL-
dc.description.affiliationDEPT PHYSIOL & BIOPHYS,SAO PAULO,BRAZIL-
dc.description.affiliationSTATE UNIV PAULISTA,DEPT EDUC PHYS,RIO CLARO,SP,BRAZIL-
dc.identifier.wosWOS:A1997WG58000021-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Pharmacology and Experimental Therapeutics-
Aparece nas coleções:Artigos, TCCs, Teses e Dissertações da Unesp

Não há nenhum arquivo associado com este item.
 

Itens do Acervo digital da UNESP são protegidos por direitos autorais reservados a menos que seja expresso o contrário.