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DC Field | Value | Language |
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dc.contributor.author | Salvadori, Daisy Maria Favero | - |
dc.contributor.author | Ribeiro, Lúcia Regina | - |
dc.contributor.author | Xiao, Y. | - |
dc.contributor.author | Boei, J. J. | - |
dc.contributor.author | Natarajan, A. T. | - |
dc.date.accessioned | 2014-05-20T15:27:59Z | - |
dc.date.accessioned | 2016-10-25T18:02:58Z | - |
dc.date.available | 2014-05-20T15:27:59Z | - |
dc.date.available | 2016-10-25T18:02:58Z | - |
dc.date.issued | 1996-09-23 | - |
dc.identifier | http://dx.doi.org/10.1016/0027-5107(96)00040-1 | - |
dc.identifier.citation | Mutation Research-fundamental and Molecular Mechanisms of Mutagenesis. Amsterdam: Elsevier B.V., v. 356, n. 2, p. 163-170, 1996. | - |
dc.identifier.issn | 0027-5107 | - |
dc.identifier.uri | http://hdl.handle.net/11449/37895 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/37895 | - |
dc.description.abstract | In the present paper, the protective effect of beta-carotene was evaluated after whole body exposure of mice to 2 Gy of X-rays. Splenocytes, reticulocytes, bone marrow cells and spermatids were evaluated for the frequency of micronuclei (MN) induced by X-rays. Mice were treated (gavage) with beta-carotene (10, 25 and 50 mg/kg b.w.) for 5 consecutive days and, 4 h after the last treatment, the animals were irradiated. The results obtained showed different frequencies of X-ray-induced-MN between different cell populations analysed and also different response of these cells to the beta-carotene treatment. The radioprotective effect of beta-carotene was observed in splenocytes, reticulocytes, and spermatids but not in bone marrow cells. No dose-response relationship for beta-carotene was detected. The time of sampling, the sensitivity of the cells as well as the antioxidant activity of beta-carotene are discussed as important factors for the radioprotective action of this provitamin. | en |
dc.format.extent | 163-170 | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.source | Web of Science | - |
dc.subject | beta-carotene | pt |
dc.subject | radioprotectors | pt |
dc.subject | antimutagenicity | pt |
dc.subject | micronucleus | pt |
dc.title | Radioprotection of beta-carotene evaluated on mouse somatic and germ cells | en |
dc.type | outro | - |
dc.contributor.institution | LEIDEN STATE UNIV | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | LEIDEN STATE UNIV,SYLVIUS LAB,MGC DEPT RADIAT GENET & CHEM MUTAGENESIS,NL-2333 AL LEIDEN,NETHERLANDS | - |
dc.identifier.doi | 10.1016/0027-5107(96)00040-1 | - |
dc.identifier.wos | WOS:A1996VJ55900005 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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