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dc.contributor.authorSalvadori, Daisy Maria Favero-
dc.contributor.authorRibeiro, Lúcia Regina-
dc.contributor.authorXiao, Y.-
dc.contributor.authorBoei, J. J.-
dc.contributor.authorNatarajan, A. T.-
dc.date.accessioned2014-05-20T15:27:59Z-
dc.date.accessioned2016-10-25T18:02:58Z-
dc.date.available2014-05-20T15:27:59Z-
dc.date.available2016-10-25T18:02:58Z-
dc.date.issued1996-09-23-
dc.identifierhttp://dx.doi.org/10.1016/0027-5107(96)00040-1-
dc.identifier.citationMutation Research-fundamental and Molecular Mechanisms of Mutagenesis. Amsterdam: Elsevier B.V., v. 356, n. 2, p. 163-170, 1996.-
dc.identifier.issn0027-5107-
dc.identifier.urihttp://hdl.handle.net/11449/37895-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/37895-
dc.description.abstractIn the present paper, the protective effect of beta-carotene was evaluated after whole body exposure of mice to 2 Gy of X-rays. Splenocytes, reticulocytes, bone marrow cells and spermatids were evaluated for the frequency of micronuclei (MN) induced by X-rays. Mice were treated (gavage) with beta-carotene (10, 25 and 50 mg/kg b.w.) for 5 consecutive days and, 4 h after the last treatment, the animals were irradiated. The results obtained showed different frequencies of X-ray-induced-MN between different cell populations analysed and also different response of these cells to the beta-carotene treatment. The radioprotective effect of beta-carotene was observed in splenocytes, reticulocytes, and spermatids but not in bone marrow cells. No dose-response relationship for beta-carotene was detected. The time of sampling, the sensitivity of the cells as well as the antioxidant activity of beta-carotene are discussed as important factors for the radioprotective action of this provitamin.en
dc.format.extent163-170-
dc.language.isoeng-
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.subjectbeta-carotenept
dc.subjectradioprotectorspt
dc.subjectantimutagenicitypt
dc.subjectmicronucleuspt
dc.titleRadioprotection of beta-carotene evaluated on mouse somatic and germ cellsen
dc.typeoutro-
dc.contributor.institutionLEIDEN STATE UNIV-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationLEIDEN STATE UNIV,SYLVIUS LAB,MGC DEPT RADIAT GENET & CHEM MUTAGENESIS,NL-2333 AL LEIDEN,NETHERLANDS-
dc.identifier.doi10.1016/0027-5107(96)00040-1-
dc.identifier.wosWOS:A1996VJ55900005-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofMutation Research: Fundamental and Molecular Mechanisms of Mutagenesis-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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