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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/38713
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dc.contributor.authorMatsubara, Luiz Shiguero-
dc.contributor.authorMachado, PEA-
dc.date.accessioned2014-05-20T15:29:02Z-
dc.date.accessioned2016-10-25T18:04:14Z-
dc.date.available2014-05-20T15:29:02Z-
dc.date.available2016-10-25T18:04:14Z-
dc.date.issued1991-01-01-
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_issues&pid=0100-879X&lng=en&nrm=iso-
dc.identifier.citationBrazilian Journal of Medical and Biological Research. São Paulo: Associação Bras Divulg Cientifica, v. 24, n. 5, p. 449-454, 1991.-
dc.identifier.issn0100-879X-
dc.identifier.urihttp://hdl.handle.net/11449/38713-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/38713-
dc.description.abstract1. In order to investigate the effect of aging on the erythrocyte glutathione system, total glutathione (GSH), glutathione reductase (GSH-red) and glutathione peroxidase (GSH-px) levels were measured in erythrocytes from 33 young (mean age = 30.5 +/- 9.7 years) and 28 aged (mean age = 68.9 +/- 11.4 years) healthy individuals.2. GSH was 3.5 +/- 1.8-mu-M/g Hb for the young group, a value significantly greater (P < 0.01) than 2.3 +/- 0.9-mu-M/g Hb found for the aged group. Similarly, GSH-red activity, 5.5 +/- 1.8 IU/g Hb, was higher (P < 0.05) for the young group than 3.4 +/- 0.9 IU/g Hb found for the aged group. The GSH-px activity levels for the young group, 21.1 +/- 5.9 IU/g Hb, were significantly greater (P < 0.01) than 12.0 +/- 3.3 IU/g Hb for the aged group. The lower activity detected in the aged group for all of these parameters of the glutathione redox system was not related to low levels of hematocrit or hemoglobin.3. There was no statistical difference in the activation coefficient (AC) of reductase (+FAD/-FAD) between groups, which seems to indicate that the lower activity of glutathione reductase observed in the aged group was not due to riboflavin deficiency.4. Additional information is required to determine the mechanisms controlling the glutathione redox system and its role in the aging process.en
dc.format.extent449-454-
dc.language.isoeng-
dc.publisherAssociação Brasileira de Divulgação Científica (ABRADIC)-
dc.sourceWeb of Science-
dc.subjectGLUTATHIONEpt
dc.subjectGLUTATHIONE REDUCTASEpt
dc.subjectGLUTATHIONE PEROXIDASEpt
dc.subjectAGINGpt
dc.titleAGE-RELATED-CHANGES OF GLUTATHIONE CONTENT, GLUTATHIONE-REDUCTASE AND GLUTATHIONE-PEROXIDASE ACTIVITY OF HUMAN ERYTHROCYTESen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUNIV ESTADUAL PAULISTA,FAC MED BOT,DEPT CLIN MED,BR-18610 BOTUCATU,SP,BRAZIL-
dc.description.affiliationUnespUNIV ESTADUAL PAULISTA,FAC MED BOT,DEPT CLIN MED,BR-18610 BOTUCATU,SP,BRAZIL-
dc.identifier.wosWOS:A1991FZ25500002-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofBrazilian Journal of Medical and Biological Research-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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