Please use this identifier to cite or link to this item:
http://acervodigital.unesp.br/handle/11449/38945
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mattar, L. | - |
dc.contributor.author | Maffei, Francisco Humberto de Abreu | - |
dc.contributor.author | Nader, H. B. | - |
dc.contributor.author | Dietrich, C. P. | - |
dc.contributor.author | Curi, P. R. | - |
dc.date.accessioned | 2014-05-20T15:29:20Z | - |
dc.date.accessioned | 2016-10-25T18:04:35Z | - |
dc.date.available | 2014-05-20T15:29:20Z | - |
dc.date.available | 2016-10-25T18:04:35Z | - |
dc.date.issued | 1994-09-15 | - |
dc.identifier | http://dx.doi.org/10.1016/0049-3848(94)90171-6 | - |
dc.identifier.citation | Thrombosis Research. Oxford: Pergamon-Elsevier B.V., v. 75, n. 6, p. 591-599, 1994. | - |
dc.identifier.issn | 0049-3848 | - |
dc.identifier.uri | http://hdl.handle.net/11449/38945 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/38945 | - |
dc.description.abstract | Heparin is the most frequently used drug for the prevention and treatment of thrombosis. Its use, however, is restricted by its side-effects. To study the efficacy of other glycosaminoglycans that could substitute heparin in the management of arterial thrombosis, 60 guinea-pigs were randomly allocated into 6 groups: G1= control, G2= heparin (150 IU/kg), G3= heparan sulfate from beef pancreas (2.5 mg/kg), G4= heparan sulfate from beef lung (2.5 mg/kg), G5= N-acetylated heparan from beef pancreas, G6= dermatan sulfate from beef intestine (2.5 mg/kg). Ten minutes after intravenous injection of the drugs, thrombosis was induced by the injection of a 50% glucose solution into a segment of the right carotid artery isolated between 2 thread loops during 10 minutes. Three hours later the artery was re-exposed and if a thrombus was present it was measured, withdrawn and weighed. Thrombin time and activated partial thromboplastin time were measured in all animals. Thrombus developed in 90% of the animals in the control group, 0% in G2 and G3, 62.5% in G4, 87.5% in G5 and G6. Only in the animals treated with heparin the coagulation tests were prolonged. In conclusion, in the used dose only the heparan sulfate from beef pancreas presented an antithrombotic effect similar to heparin in this experimental model. | en |
dc.format.extent | 591-599 | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.source | Web of Science | - |
dc.subject | experimental thrombosis | pt |
dc.subject | glycosaminoglycans | pt |
dc.subject | arterial thrombosis | pt |
dc.subject | heparin | pt |
dc.subject | heparan sulfate | pt |
dc.subject | dermatan sulfate | pt |
dc.title | Effect of different glycosaminoglycans in a guinea-pig carotid-artery thrombosis model | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | ESCOLA PAULISTA MED,DEPT BIOCHEM,BR-04023 SAO PAULO,BRAZIL | - |
dc.description.affiliation | UNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO,FAC MED VET & ZOOTECN BOTUCATU,DEPT STAT,BOTUCATU,SP,BRAZIL | - |
dc.description.affiliationUnesp | UNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO,FAC MED VET & ZOOTECN BOTUCATU,DEPT STAT,BOTUCATU,SP,BRAZIL | - |
dc.identifier.doi | 10.1016/0049-3848(94)90171-6 | - |
dc.identifier.wos | WOS:A1994PF86000002 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Thrombosis Research | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.