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dc.contributor.authorCarvalho, JCT-
dc.contributor.authorSilva, MFC-
dc.contributor.authorMaciel, MAM-
dc.contributor.authorPinto, Abedala Derbli-
dc.contributor.authorNunes, D. S.-
dc.contributor.authorLima, R. M.-
dc.contributor.authorBastos, J. K.-
dc.contributor.authorSarti, S. J.-
dc.date.accessioned2014-05-20T15:29:28Z-
dc.date.accessioned2016-10-25T18:04:44Z-
dc.date.available2014-05-20T15:29:28Z-
dc.date.available2016-10-25T18:04:44Z-
dc.date.issued1996-10-01-
dc.identifierhttp://dx.doi.org/10.1055/s-2006-957925-
dc.identifier.citationPlanta Medica. Stuttgart: Georg Thieme Verlag, v. 62, n. 5, p. 402-404, 1996.-
dc.identifier.issn0032-0943-
dc.identifier.urihttp://hdl.handle.net/11449/39058-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/39058-
dc.description.abstractThe anti-inflammatory and antinociceptive effects of trans-dehydrocrotonin, isolated from the bark of Croton cajucara (Euphorbiaceae), were investigated using several animal models. The trans-dehydrocrotonin produced a significant inhibition of carrageenin-induced paw edema and cotton pellet granuloma in rats. It also inhibited the writhings in mice induced by acetic acid, but did not show a significant effect in the hot-plate test in mice. The LD(50) of t-DCTN was 555.0 mg/kg (p.o.) for mice.en
dc.format.extent402-404-
dc.language.isoeng-
dc.publisherGeorg Thieme Verlag-
dc.sourceWeb of Science-
dc.subjectCroton cajucarapt
dc.subjectEuphorbiaceaept
dc.subjecttrans-dehydrocrotoninpt
dc.subject19-nor-clerodane diterpenept
dc.subjectanti-inflammatory and antinociceptivept
dc.titleInvestigation of anti-inflammatory and antinociceptive activities of trans-dehydrocrotonin, a 19-nor-clerodane diterpene from Croton cajucara .1.en
dc.typeoutro-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)-
dc.contributor.institutionFED UNIV PARA-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUNIV SAO PAULO,FAC CIENCIAS FARMACEUT RIBEIRAO PRETO,DEPT CIENCIAS FARMACEUT,BR-14014903 RIBEIRAO PRET,SP,BRAZIL-
dc.description.affiliationUNIV FED RIO DE JANEIRO,INST QUIM,BR-21910240 RIO JANEIRO,BRAZIL-
dc.description.affiliationFED UNIV PARA,DEPT QUIM,CCEN,BR-66075900 BELEM,PARA,BRAZIL-
dc.identifier.doi10.1055/s-2006-957925-
dc.identifier.wosWOS:A1996VQ03600004-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofPlanta Medica-
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