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dc.contributor.authorPereira do Nascimento, Magda Paula-
dc.contributor.authorSoares, Ângela Maria Victoriano de Campos-
dc.contributor.authorDias-Melicio, Luciane Alarcao-
dc.contributor.authorParise-Fortes, Maria Rita-
dc.contributor.authorRodrigues Martins, Rosana Aparecida-
dc.contributor.authorNakaira, Erika Takahashi-
dc.contributor.authorSerrao Peracoil, Maria Terezinha-
dc.date.accessioned2014-05-20T15:30:01Z-
dc.date.accessioned2016-10-25T18:05:23Z-
dc.date.available2014-05-20T15:30:01Z-
dc.date.available2016-10-25T18:05:23Z-
dc.date.issued2008-07-01-
dc.identifierhttp://dx.doi.org/10.1007/s11046-007-9051-6-
dc.identifier.citationMycopathologia. Dordrecht: Springer, v. 166, n. 1, p. 25-33, 2008.-
dc.identifier.issn0301-486X-
dc.identifier.urihttp://hdl.handle.net/11449/39466-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/39466-
dc.description.abstractMultinucleated giant cells (MGC) are characteristic cells in granulomatous disorders such as paracoccidioidomycosis (PCM) and also are formed in vitro from peripheral blood mononuclear cells by several stimuli. In this study, the authors investigated in vitro formation of MGC derived from monocytes of healthy individuals, stimulated with Paracoccidioides brasiliensis antigen (PbAg), compared with other stimuli such as IFN-gamma and supernatant of Con-A-stimulated peripheral blood mononuclear cells (CM-ConA). Besides, the fungicidal activity of monocytes and monocyte-derived MGC challenged with P. brasiliensis were compared, at a ratio of one fungus per 50 monocytes. Results demonstrated that PbAg, IFN-gamma, and CM-ConA stimuli were able to induce MGC generation, with fusion indices significantly higher than control cultures. Striking results were observed when MGC induced by PbAg and IFN-gamma presented higher fungicidal activity than monocytes, submitted to the same stimuli, showing a better capacity of these cells to kill P. brasiliensis. In summary, the results suggest that PbAg is able to induce MGC generation, and these cells presented higher fungicidal activity against P. brasiliensis than monocytes.en
dc.format.extent25-33-
dc.language.isoeng-
dc.publisherSpringer-
dc.sourceWeb of Science-
dc.subjectfungicidal activityen
dc.subjectmultinucleated giant cellsen
dc.subjectparacoccidioides brasiliensisen
dc.subjectinterferon-gammaen
dc.titleFungicidal activity of human monocyte-derived multinucleated giant cells induced in vitro by Paracoccidioides brasiliensis antigenen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv Estadual Paulista, Dept Microbiol & Immunol, Biosci Inst, BR-18618000 São Paulo, Brazil-
dc.description.affiliationUniv Estadual Paulista, Dept Dermatol & Radiotherapy, Sch Med, BR-18618000 São Paulo, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Dept Microbiol & Immunol, Biosci Inst, BR-18618000 São Paulo, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Dept Dermatol & Radiotherapy, Sch Med, BR-18618000 São Paulo, Brazil-
dc.identifier.doi10.1007/s11046-007-9051-6-
dc.identifier.wosWOS:000257215400003-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofMycopathologia-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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