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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/397
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dc.contributor.authordos Santos, Marcelo L.-
dc.contributor.authorFagundes, Fabio H. R.-
dc.contributor.authorTeixeira, Bruno R. F.-
dc.contributor.authorToyama, Marcos H.-
dc.contributor.authorAparicio, Ricardo-
dc.date.accessioned2014-05-20T13:12:26Z-
dc.date.available2014-05-20T13:12:26Z-
dc.date.issued2008-05-01-
dc.identifierhttp://dx.doi.org/10.3390/ijms9050736-
dc.identifier.citationInternational Journal of Molecular Sciences. Basel: Mdpi Ag, v. 9, n. 5, p. 736-750, 2008.-
dc.identifier.issn1661-6596-
dc.identifier.urihttp://hdl.handle.net/11449/397-
dc.description.abstractBjVIII is a new myotoxic Lys49-PLA2 isolated from Bothrops jararacussu venom that exhibits atypical effects on human platelet aggregation. To better understand the mode of action of BjVIII, crystallographic studies were initiated. Two crystal forms were obtained, both containing two molecules in the asymmetric unit (ASU). Synchrotron radiation diffraction data were collected to 2.0 angstrom resolution and 1.9 angstrom resolution for crystals belonging to the space group P2(1)2(1)2(1) (a = 48.4 angstrom, b = 65.3 angstrom, c = 84.3 angstrom) and space group P3(1)21 (a = b = 55.7 angstrom, c = 127.9 angstrom), respectively. Refinement is currently in progress and the refined structures are expected to shed light on the unusual platelet aggregation activity observed for BjVIII.en
dc.format.extent736-750-
dc.language.isoeng-
dc.publisherMdpi Ag-
dc.sourceWeb of Science-
dc.subjectLys49-PLA2en
dc.subjectBothrops jararacussuen
dc.subjectplatelet aggregationen
dc.subjectphospholipase crystallographic analysisen
dc.titlePurification and preliminary crystallographic analysis of a new Lys49-PLA2 from B-jararacussuen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv Estadual Campinas, Lab Biol Estrutural & Cristalog, Inst Quim, BR-13083970 Campinas, SP, Brazil-
dc.description.affiliationUniv Estadual Campinas, Inst Biol, Campinas, SP, Brazil-
dc.description.affiliationUNESP, CLP, Lab Quim Macromol, Sao Vicente, SP, Brazil-
dc.description.affiliationUnespUNESP, CLP, Lab Quim Macromol, Sao Vicente, SP, Brazil-
dc.identifier.doi10.3390/ijms9050736-
dc.identifier.wosWOS:000256308000004-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileWOS000256308000004.pdf-
dc.relation.ispartofInternational Journal of Molecular Sciences-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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