Please use this identifier to cite or link to this item:
http://acervodigital.unesp.br/handle/11449/397
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | dos Santos, Marcelo L. | - |
dc.contributor.author | Fagundes, Fabio H. R. | - |
dc.contributor.author | Teixeira, Bruno R. F. | - |
dc.contributor.author | Toyama, Marcos H. | - |
dc.contributor.author | Aparicio, Ricardo | - |
dc.date.accessioned | 2014-05-20T13:12:26Z | - |
dc.date.available | 2014-05-20T13:12:26Z | - |
dc.date.issued | 2008-05-01 | - |
dc.identifier | http://dx.doi.org/10.3390/ijms9050736 | - |
dc.identifier.citation | International Journal of Molecular Sciences. Basel: Mdpi Ag, v. 9, n. 5, p. 736-750, 2008. | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | http://hdl.handle.net/11449/397 | - |
dc.description.abstract | BjVIII is a new myotoxic Lys49-PLA2 isolated from Bothrops jararacussu venom that exhibits atypical effects on human platelet aggregation. To better understand the mode of action of BjVIII, crystallographic studies were initiated. Two crystal forms were obtained, both containing two molecules in the asymmetric unit (ASU). Synchrotron radiation diffraction data were collected to 2.0 angstrom resolution and 1.9 angstrom resolution for crystals belonging to the space group P2(1)2(1)2(1) (a = 48.4 angstrom, b = 65.3 angstrom, c = 84.3 angstrom) and space group P3(1)21 (a = b = 55.7 angstrom, c = 127.9 angstrom), respectively. Refinement is currently in progress and the refined structures are expected to shed light on the unusual platelet aggregation activity observed for BjVIII. | en |
dc.format.extent | 736-750 | - |
dc.language.iso | eng | - |
dc.publisher | Mdpi Ag | - |
dc.source | Web of Science | - |
dc.subject | Lys49-PLA2 | en |
dc.subject | Bothrops jararacussu | en |
dc.subject | platelet aggregation | en |
dc.subject | phospholipase crystallographic analysis | en |
dc.title | Purification and preliminary crystallographic analysis of a new Lys49-PLA2 from B-jararacussu | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual de Campinas (UNICAMP) | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Univ Estadual Campinas, Lab Biol Estrutural & Cristalog, Inst Quim, BR-13083970 Campinas, SP, Brazil | - |
dc.description.affiliation | Univ Estadual Campinas, Inst Biol, Campinas, SP, Brazil | - |
dc.description.affiliation | UNESP, CLP, Lab Quim Macromol, Sao Vicente, SP, Brazil | - |
dc.description.affiliationUnesp | UNESP, CLP, Lab Quim Macromol, Sao Vicente, SP, Brazil | - |
dc.identifier.doi | 10.3390/ijms9050736 | - |
dc.identifier.wos | WOS:000256308000004 | - |
dc.rights.accessRights | Acesso aberto | - |
dc.identifier.file | WOS000256308000004.pdf | - |
dc.relation.ispartof | International Journal of Molecular Sciences | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.