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DC Field | Value | Language |
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dc.contributor.author | Marangoni, N. R. | - |
dc.contributor.author | Melo, G. D. | - |
dc.contributor.author | Moraes, O. C. | - |
dc.contributor.author | Souza, M. S. | - |
dc.contributor.author | Perri, Silvia Helena Venturoli | - |
dc.contributor.author | Machado, Gisele Fabrino | - |
dc.date.accessioned | 2014-05-20T15:30:56Z | - |
dc.date.accessioned | 2016-10-25T18:06:38Z | - |
dc.date.available | 2014-05-20T15:30:56Z | - |
dc.date.available | 2016-10-25T18:06:38Z | - |
dc.date.issued | 2011-06-01 | - |
dc.identifier | http://dx.doi.org/10.1111/j.1365-3024.2011.01285.x | - |
dc.identifier.citation | Parasite Immunology. Malden: Wiley-blackwell, v. 33, n. 6, p. 330-334, 2011. | - |
dc.identifier.issn | 0141-9838 | - |
dc.identifier.uri | http://hdl.handle.net/11449/40219 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/40219 | - |
dc.description.abstract | P>Inflammation causes increases in the level of matrix metalloproteinases (MMPs), which, in central nervous system (CNS), are associated with neuroinflammation and disruption of blood-brain barrier. Analysis of cerebrospinal fluid (CSF) is pivotal for detecting diseases in CNS and, although a specific diagnosis may not be achieved, this analysis is helpful to confirm the diagnosis or to rule out relevant differential diagnoses. This study examined the levels of MMP-2 and MMP-9 in the CSF of dogs using gelatin zymography to verify possible alterations in these enzymes during natural systemic infection with Leishmania chagasi. Latent and active forms of MMP-2 were detected in some dogs of both groups, with high levels in the control group. In contrast, latent and active forms of MMP-9 were detected only in some animals with leishmaniasis. These results clearly demonstrate that MMP-9 is elevated in CSF of dogs with visceral leishmaniasis (VL). Although these results are preliminary, they suggest that MMP-9 might play a role in disruption of blood-brain barrier and/or blood-CSF barrier. While the presence of MMPs in CSF is not a condition exclusive to VL, their presence and persistence in CSF supports the hypothesis of an inflammatory state within CNS of dogs with VL. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.format.extent | 330-334 | - |
dc.language.iso | eng | - |
dc.publisher | Wiley-Blackwell | - |
dc.source | Web of Science | - |
dc.subject | central nervous system | en |
dc.subject | inflammation | en |
dc.subject | Leishmania chagasi | en |
dc.subject | MMP-2 | en |
dc.subject | MMP-9 | en |
dc.subject | zymography | en |
dc.title | Levels of matrix metalloproteinase-2 and metalloproteinase-9 in the cerebrospinal fluid of dogs with visceral leishmaniasis | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | UNESP Univ Estadual Paulista, Dept Anim Clin Surg & Reprod, Coll Vet Med, São Paulo, Brazil | - |
dc.description.affiliation | UNESP Univ Estadual Paulista, Dept Anim Prod & Hlth, Coll Vet Med, São Paulo, Brazil | - |
dc.description.affiliationUnesp | UNESP Univ Estadual Paulista, Dept Anim Clin Surg & Reprod, Coll Vet Med, São Paulo, Brazil | - |
dc.description.affiliationUnesp | UNESP Univ Estadual Paulista, Dept Anim Prod & Hlth, Coll Vet Med, São Paulo, Brazil | - |
dc.description.sponsorshipId | FAPESP: 05/60132 | - |
dc.description.sponsorshipId | FAPESP: 06/56724-3 | - |
dc.description.sponsorshipId | FAPESP: 08/57637-2 | - |
dc.identifier.doi | 10.1111/j.1365-3024.2011.01285.x | - |
dc.identifier.wos | WOS:000290430600003 | - |
dc.rights.accessRights | Acesso aberto | - |
dc.relation.ispartof | Parasite Immunology | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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