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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/40597
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dc.contributor.authorBraga-Neto, Pedro-
dc.contributor.authorDutra, Livia Almeida-
dc.contributor.authorPedroso, Jose Luiz-
dc.contributor.authorFelicio, Andre C.-
dc.contributor.authorAlessi, Helena-
dc.contributor.authorSantos-Galduroz, Ruth F.-
dc.contributor.authorBertolucci, Paulo Henrique F.-
dc.contributor.authorCastiglioni, Mario Luiz V.-
dc.contributor.authorBressan, Rodrigo Affonseca-
dc.contributor.authorJara de Garrido, Griselda Esther-
dc.contributor.authorPovoas Barsottini, Orlando Graziani-
dc.contributor.authorJackowski, Andrea-
dc.date.accessioned2014-05-20T15:31:28Z-
dc.date.accessioned2016-10-25T18:07:19Z-
dc.date.available2014-05-20T15:31:28Z-
dc.date.available2016-10-25T18:07:19Z-
dc.date.issued2012-12-01-
dc.identifierhttp://dx.doi.org/10.1007/s12311-012-0354-x-
dc.identifier.citationCerebellum. New York: Springer, v. 11, n. 4, p. 1037-1044, 2012.-
dc.identifier.issn1473-4222-
dc.identifier.urihttp://hdl.handle.net/11449/40597-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/40597-
dc.description.abstractCognitive and olfactory impairments have previously been demonstrated in patients with spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD)-SCA3/MJD. We investigated changes in regional cerebral blood flow (rCBF) using single-photon emission computed tomography (SPECT) imaging in a cohort of Brazilian patients with SCA3/MJD. The aim of the present study was to evaluate the correlation among rCBF, cognitive deficits, and olfactory dysfunction in SCA3/MJD. Twenty-nine genetically confirmed SCA3/MJD patients and 25 control subjects were enrolled in the study. The severity of cerebellar symptoms was measured using the International Cooperative Ataxia Rating Scale and the Scale for the Assessment and Rating of Ataxia. Psychiatric symptoms were evaluated by the Hamilton Anxiety Scale and Beck Depression Inventory. The neuropsychological assessment consisted of Spatial Span, Symbol Search, Picture Completion, the Stroop Color Word Test, Trail Making Test (TMT), and Phonemic Verbal Fluency. Subjects were also submitted to odor identification evaluation using the 16-item Sniffin' Sticks. SPECT was performed using ethyl cysteine dimer labeled with technetium-99m. SCA3/MJD patients showed reduced brain perfusion in the cerebellum, temporal, limbic, and occipital lobes compared to control subjects (pFDR < 0.001). A significant positive correlation was found between the Picture Completion test and perfusion of the left parahippocampal gyrus and basal ganglia in the patient group as well as a negative correlation between the TMT part A and bilateral thalamus perfusion. The visuospatial system is affected in patients with SCA3/MJD and may be responsible for the cognitive deficits seen in this disease.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipInstituto Albert Einstein de Ensino e Pesquisa-
dc.format.extent1037-1044-
dc.language.isoeng-
dc.publisherSpringer-
dc.sourceWeb of Science-
dc.subjectMachado-Joseph diseaseen
dc.subjectSpinocerebellar ataxia type 3en
dc.subjectCognitionen
dc.subjectOlfactionen
dc.subjectCognitive deficitsen
dc.subjectSPECTen
dc.titleCognitive Deficits in Machado-Joseph Disease Correlate with Hypoperfusion of Visual System Areasen
dc.typeoutro-
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)-
dc.contributor.institutionUniversidade Federal do ABC (UFABC)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniv Western Australia-
dc.description.affiliationUniv Fed São Paulo, Ataxia Unit, Dept Neurol & Neurosurg, São Paulo, Brazil-
dc.description.affiliationUniv Fed São Paulo, Behav Neurol Sect, Dept Neurol & Neurosurg, São Paulo, Brazil-
dc.description.affiliationUFABC, Ctr Math Comp & Cognit, São Paulo, Brazil-
dc.description.affiliationUniv Estadual Paulista, Inst Biosci, São Paulo, Brazil-
dc.description.affiliationUniv Fed São Paulo, Nucl Med Sect, Dept Radiol, São Paulo, Brazil-
dc.description.affiliationUniv Fed São Paulo, Lab Interdisciplinar Neurociencias Clin LiNC, Dept Psychiat, São Paulo, Brazil-
dc.description.affiliationUniv Western Australia, Med Res Ctr, Western Australian Ctr Hlth & Ageing, Crawley, Australia-
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biosci, São Paulo, Brazil-
dc.identifier.doi10.1007/s12311-012-0354-x-
dc.identifier.wosWOS:000311249400023-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofCerebellum-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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