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DC Field | Value | Language |
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dc.contributor.author | Crispim, J. C. O. | - |
dc.contributor.author | Wastowski, I. J. | - |
dc.contributor.author | Rassi, D. M. | - |
dc.contributor.author | Mendes-Junior Silva, C. T. | - |
dc.contributor.author | Bassi, C. | - |
dc.contributor.author | Castelli, E. C. | - |
dc.contributor.author | Costa, R. S. | - |
dc.contributor.author | Saber, L. T. | - |
dc.contributor.author | Silva, T. G. A. | - |
dc.contributor.author | Donadi, E. A. | - |
dc.date.accessioned | 2014-05-20T15:31:34Z | - |
dc.date.accessioned | 2016-10-25T18:07:27Z | - |
dc.date.available | 2014-05-20T15:31:34Z | - |
dc.date.available | 2016-10-25T18:07:27Z | - |
dc.date.issued | 2010-12-01 | - |
dc.identifier | http://dx.doi.org/10.1016/j.transproceed.2010.10.014 | - |
dc.identifier.citation | Transplantation Proceedings. New York: Elsevier B.V., v. 42, n. 10, p. 4505-4508, 2010. | - |
dc.identifier.issn | 0041-1345 | - |
dc.identifier.uri | http://hdl.handle.net/11449/40664 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/40664 | - |
dc.description.abstract | Background. Despite advances in immunosuppressive therapy in the past decade, allograft rejection remains an important cause of kidney graft failure. Cytokines play a major role in the inflammatory and immune responses that mediate allograft outcomes. Several studies have shown that the production of cytokines varies among individuals. These variations are determined by genetic polymorphisms, most commonly within the regulatory region of cytokine genes. The aim of the present study was to assess the effect of allelic variation on acute rejection episodes (ARE) or chronic allograft nephropathy (CAN) after kidney transplantation.Methods. To determine a possible correlation between the interferon (INF)-gamma +874 polymorphism and kidney allograft outcome, we isolated genomic DNA from 74 patients who underwent isolated kidney allografts and were classified into 2 groups-a rejection and a nonrejection group-for comparison with a control group of 163 healthy subjects.Results. We genotyped INF-gamma +874 polymorphisms in all groups. The transplant group showed a significantly increased homozygous genotype T/T (P = .0118) compared with healthy controls. Similarly, considering only patients with CAN, the homozygous genotype T/T (P = .0067) was significantly increased compared with the healthy controls. The rejection group indicated a significant increased homozygous genotype Tic compared with the control group (P = .0061).Conclusion. Homozygous genotype T/T was associated with increased levels of INF-gamma and greater numbers among the rejection and CAN cohorts. | en |
dc.format.extent | 4505-4508 | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.source | Web of Science | - |
dc.title | Interferon-gamma+874 Polymorphism in the First Intron of the Human Interferon-gamma Gene and Kidney Allograft Outcome | en |
dc.type | outro | - |
dc.contributor.institution | Universidade de São Paulo (USP) | - |
dc.contributor.institution | Universidade Federal do Rio Grande do Norte (UFRN) | - |
dc.contributor.institution | Univ Fed Mato Grosso | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Univ São Paulo, Dept Biochem & Immunol, Sch Med Ribeirao Preto, São Paulo, Brazil | - |
dc.description.affiliation | Fac Pharmaceut Sci UFRN, Dept Clin & Toxicol Anal, Natal, RN, Brazil | - |
dc.description.affiliation | Univ São Paulo, Div Clin Immunol, Sch Med Ribeirao Preto, Dept Med, São Paulo, Brazil | - |
dc.description.affiliation | Univ São Paulo, Dept Chem, Fac Philosophy Sci & Letters Ribeirao Preto, São Paulo, Brazil | - |
dc.description.affiliation | Univ Fed Mato Grosso, Dept Basics Sci Hlth, Sch Pharmaceut Sci, Campo Grande, Brazil | - |
dc.description.affiliation | Univ São Paulo, Dept Pathol, Sch Med Ribeirao Preto, São Paulo, Brazil | - |
dc.description.affiliation | Univ São Paulo, FMRP USP, Sch Med Ribeirao Preto, São Paulo, Brazil | - |
dc.description.affiliation | Univ Estadual Paulista, Dept Clin Anal, Sch Pharmaceut Sci, São Paulo, Brazil | - |
dc.description.affiliationUnesp | Univ Estadual Paulista, Dept Clin Anal, Sch Pharmaceut Sci, São Paulo, Brazil | - |
dc.identifier.doi | 10.1016/j.transproceed.2010.10.014 | - |
dc.identifier.wos | WOS:000285732200142 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Transplantation Proceedings | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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