You are in the accessibility menu

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/40796
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBraga-Neto, Pedro-
dc.contributor.authorFelicio, Andre C.-
dc.contributor.authorHoexter, Marcelo Q.-
dc.contributor.authorPedroso, Jose Luiz-
dc.contributor.authorDutra, Livia Almeida-
dc.contributor.authorAlessi, Helena-
dc.contributor.authorMinett, Thais-
dc.contributor.authorSantos-Galduroz, Ruth F.-
dc.contributor.authorda Rocha, Antonio Jose-
dc.contributor.authorGarcia, Lucas A. L.-
dc.contributor.authorBertolucci, Paulo Henrique F.-
dc.contributor.authorBressan, Rodrigo A.-
dc.contributor.authorPovoas Barsottini, Orlando Graziani-
dc.date.accessioned2014-05-20T15:31:44Z-
dc.date.accessioned2016-10-25T18:07:41Z-
dc.date.available2014-05-20T15:31:44Z-
dc.date.available2016-10-25T18:07:41Z-
dc.date.issued2012-08-01-
dc.identifierhttp://dx.doi.org/10.1016/j.parkreldis.2012.04.015-
dc.identifier.citationParkinsonism & Related Disorders. Oxford: Elsevier B.V., v. 18, n. 7, p. 854-858, 2012.-
dc.identifier.issn1353-8020-
dc.identifier.urihttp://hdl.handle.net/11449/40796-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/40796-
dc.description.abstractCognitive and olfactory impairments have been demonstrated in patients with Machado-Joseph disease (MJD), and a possible relationship with dopaminergic dysfunction is implicated. However, there is still controversy regarding the pattern of striatal dopaminergic dysfunction in patients with MJD. In this study, we investigated whether these patients had different Dopamine Transporter (DAT) densities as compared to healthy subjects, and correlated these data with cognitive performance and sense of smell. Twenty-two MJD patients and 20 control subjects were enrolled. The neuropsychological assessment comprised the Spatial Span, Symbol Search, Picture Completion, Stroop Color Word Test, Trail Making Test and Phonemic Verbal Fluency test. The 16-item Sniffin' Sticks was used to evaluate odor identification. DAT imaging was performed using the SPECT radioligand [Tc-99m]-TRODAT-1, alongside with Magnetic Resonance imaging. Patients with MJD showed significantly lower DAT density in the caudate (1.34 +/- 0.27 versus 2.02 +/- 0.50, p < 0.001), posterior putamen (0.81 +/- 0.32 versus 1.32 +/- 0.34, p < 0.001) and anterior putamen (1.10 +/- 0.31 versus 1.85 +/- 0.45, p < 0.001) compared with healthy controls. The putamen/caudate ratio was also significantly lower in patients compared with controls (0.73 +/- 0.038 versus 0.85 +/- 0.032, p = 0.027). Even though we had only two patients with parkinsonisrn, we detected striatal dopaminergic deficits in those patients. No significant correlations were detected between DAT density and cognitive performance or Sniffin' Sticks scores. The data suggests that striatal dopamine deficit is not involved in cognitive or sense of smell deficits. This finding raises the possibility of extra-striatal dopamine and other neurotransmitter system involvement or of cerebellum neurodegeneration exerting a direct influence on cognitive and sensorial information processing in MJD. (C) 2012 Elsevier Ltd. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.format.extent854-858-
dc.language.isoeng-
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.subjectSpinocerebellar ataxia type 3en
dc.subjectMachado-Joseph diseaseen
dc.subjectCognitive deficitsen
dc.subjectDopamine transporteren
dc.subjectCognitionen
dc.subjectOlfactionen
dc.titleCognitive and olfactory deficits in Machado-Joseph disease: A dopamine transporter studyen
dc.typeoutro-
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)-
dc.contributor.institutionUniv Cambridge-
dc.contributor.institutionUniversidade Federal do ABC (UFABC)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionSanta Casa Misericordia São Paulo-
dc.contributor.institutionBeneficencia Portuguesa São Paulo-
dc.description.affiliationUniv Fed São Paulo, Dept Neurol & Neurosurg, Behav Neurol Sect, Ataxia Unit, BR-04039002 São Paulo, Brazil-
dc.description.affiliationUniv Fed São Paulo, Dept Psychiat, LiNC, BR-04039002 São Paulo, Brazil-
dc.description.affiliationUniv Fed São Paulo, Dept Prevent Med, BR-04039002 São Paulo, Brazil-
dc.description.affiliationUniv Cambridge, Dept Publ Hlth & Primary Care, Cambridge CB2 1TN, England-
dc.description.affiliationUFABC, Ctr Math Comp & Cognit, São Paulo, Brazil-
dc.description.affiliationUniv Estadual Paulista, Inst Biosci, São Paulo, Brazil-
dc.description.affiliationSanta Casa Misericordia São Paulo, Neuroradiol Sect, São Paulo, Brazil-
dc.description.affiliationBeneficencia Portuguesa São Paulo, MEDIMAGEM, São Paulo, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biosci, São Paulo, Brazil-
dc.identifier.doi10.1016/j.parkreldis.2012.04.015-
dc.identifier.wosWOS:000308970200010-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofParkinsonism & Related Disorders-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.
 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.