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http://acervodigital.unesp.br/handle/11449/40796
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DC Field | Value | Language |
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dc.contributor.author | Braga-Neto, Pedro | - |
dc.contributor.author | Felicio, Andre C. | - |
dc.contributor.author | Hoexter, Marcelo Q. | - |
dc.contributor.author | Pedroso, Jose Luiz | - |
dc.contributor.author | Dutra, Livia Almeida | - |
dc.contributor.author | Alessi, Helena | - |
dc.contributor.author | Minett, Thais | - |
dc.contributor.author | Santos-Galduroz, Ruth F. | - |
dc.contributor.author | da Rocha, Antonio Jose | - |
dc.contributor.author | Garcia, Lucas A. L. | - |
dc.contributor.author | Bertolucci, Paulo Henrique F. | - |
dc.contributor.author | Bressan, Rodrigo A. | - |
dc.contributor.author | Povoas Barsottini, Orlando Graziani | - |
dc.date.accessioned | 2014-05-20T15:31:44Z | - |
dc.date.accessioned | 2016-10-25T18:07:41Z | - |
dc.date.available | 2014-05-20T15:31:44Z | - |
dc.date.available | 2016-10-25T18:07:41Z | - |
dc.date.issued | 2012-08-01 | - |
dc.identifier | http://dx.doi.org/10.1016/j.parkreldis.2012.04.015 | - |
dc.identifier.citation | Parkinsonism & Related Disorders. Oxford: Elsevier B.V., v. 18, n. 7, p. 854-858, 2012. | - |
dc.identifier.issn | 1353-8020 | - |
dc.identifier.uri | http://hdl.handle.net/11449/40796 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/40796 | - |
dc.description.abstract | Cognitive and olfactory impairments have been demonstrated in patients with Machado-Joseph disease (MJD), and a possible relationship with dopaminergic dysfunction is implicated. However, there is still controversy regarding the pattern of striatal dopaminergic dysfunction in patients with MJD. In this study, we investigated whether these patients had different Dopamine Transporter (DAT) densities as compared to healthy subjects, and correlated these data with cognitive performance and sense of smell. Twenty-two MJD patients and 20 control subjects were enrolled. The neuropsychological assessment comprised the Spatial Span, Symbol Search, Picture Completion, Stroop Color Word Test, Trail Making Test and Phonemic Verbal Fluency test. The 16-item Sniffin' Sticks was used to evaluate odor identification. DAT imaging was performed using the SPECT radioligand [Tc-99m]-TRODAT-1, alongside with Magnetic Resonance imaging. Patients with MJD showed significantly lower DAT density in the caudate (1.34 +/- 0.27 versus 2.02 +/- 0.50, p < 0.001), posterior putamen (0.81 +/- 0.32 versus 1.32 +/- 0.34, p < 0.001) and anterior putamen (1.10 +/- 0.31 versus 1.85 +/- 0.45, p < 0.001) compared with healthy controls. The putamen/caudate ratio was also significantly lower in patients compared with controls (0.73 +/- 0.038 versus 0.85 +/- 0.032, p = 0.027). Even though we had only two patients with parkinsonisrn, we detected striatal dopaminergic deficits in those patients. No significant correlations were detected between DAT density and cognitive performance or Sniffin' Sticks scores. The data suggests that striatal dopamine deficit is not involved in cognitive or sense of smell deficits. This finding raises the possibility of extra-striatal dopamine and other neurotransmitter system involvement or of cerebellum neurodegeneration exerting a direct influence on cognitive and sensorial information processing in MJD. (C) 2012 Elsevier Ltd. All rights reserved. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.format.extent | 854-858 | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.source | Web of Science | - |
dc.subject | Spinocerebellar ataxia type 3 | en |
dc.subject | Machado-Joseph disease | en |
dc.subject | Cognitive deficits | en |
dc.subject | Dopamine transporter | en |
dc.subject | Cognition | en |
dc.subject | Olfaction | en |
dc.title | Cognitive and olfactory deficits in Machado-Joseph disease: A dopamine transporter study | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | - |
dc.contributor.institution | Univ Cambridge | - |
dc.contributor.institution | Universidade Federal do ABC (UFABC) | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Santa Casa Misericordia São Paulo | - |
dc.contributor.institution | Beneficencia Portuguesa São Paulo | - |
dc.description.affiliation | Univ Fed São Paulo, Dept Neurol & Neurosurg, Behav Neurol Sect, Ataxia Unit, BR-04039002 São Paulo, Brazil | - |
dc.description.affiliation | Univ Fed São Paulo, Dept Psychiat, LiNC, BR-04039002 São Paulo, Brazil | - |
dc.description.affiliation | Univ Fed São Paulo, Dept Prevent Med, BR-04039002 São Paulo, Brazil | - |
dc.description.affiliation | Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge CB2 1TN, England | - |
dc.description.affiliation | UFABC, Ctr Math Comp & Cognit, São Paulo, Brazil | - |
dc.description.affiliation | Univ Estadual Paulista, Inst Biosci, São Paulo, Brazil | - |
dc.description.affiliation | Santa Casa Misericordia São Paulo, Neuroradiol Sect, São Paulo, Brazil | - |
dc.description.affiliation | Beneficencia Portuguesa São Paulo, MEDIMAGEM, São Paulo, Brazil | - |
dc.description.affiliationUnesp | Univ Estadual Paulista, Inst Biosci, São Paulo, Brazil | - |
dc.identifier.doi | 10.1016/j.parkreldis.2012.04.015 | - |
dc.identifier.wos | WOS:000308970200010 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Parkinsonism & Related Disorders | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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