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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/41469
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dc.contributor.authorSangiorgio, F.-
dc.contributor.authorSakate, M.-
dc.contributor.authorNogueira, R. M. B.-
dc.contributor.authorTostes, R. A.-
dc.date.accessioned2014-05-20T15:32:36Z-
dc.date.accessioned2016-10-25T18:08:54Z-
dc.date.available2014-05-20T15:32:36Z-
dc.date.available2016-10-25T18:08:54Z-
dc.date.issued2008-01-01-
dc.identifierhttp://dx.doi.org/10.1590/S1678-91992008000100007-
dc.identifier.citationJournal of Venomous Animals and Toxins Including Tropical Diseases. Botucatu: Cevap-unesp, v. 14, n. 1, p. 82-99, 2008.-
dc.identifier.issn1678-9199-
dc.identifier.urihttp://hdl.handle.net/11449/41469-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/41469-
dc.description.abstractThe present work evaluated histopathological aspects in experimental envenomation of dogs with Crotalus durissus terrificus venom. Twenty-eight mixed breed adult dogs were divided into three groups of seven animals each: Group I only venom; Group II - venom + 50ml antiophidic serum + fluid therapy; Group III venom + 50ml antiophidic serum + fluid therapy + urine alkalization. Lyophilized venom of Crotalus durissus terrificus was reconstituted in saline solution and inoculated subcutaneously at the dose of 1mg/kg body weight. Three animals of each group were subjected to euthanasia, and their muscular tissue, brain, spleen, kidneys, heart, lungs, stomach, small and large intestines, and popliteal lymph node fragments were collected for histopathological evaluation. There was myonecrosis in the inoculated limb, renal tubular degeneration, lymphoid hyperplasia of spleen, and unspecific reactive hepatitis. These results show the antigenicity and action of the venom on the immune system.en
dc.format.extent82-99-
dc.language.isoeng-
dc.publisherUniversidade Estadual Paulista (UNESP), Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP)-
dc.sourceWeb of Science-
dc.subjecthistopathologyen
dc.subjectCrotalus durissus terrificusen
dc.subjectdogsen
dc.subjecttreatmenten
dc.subjectintoxicationen
dc.titleHistopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus Venomen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade do Oeste Paulista (UNOESTE)-
dc.contributor.institutionCESUMAR-
dc.description.affiliationSão Paulo State Univ UNESP, Dept Small Anim Med Clin & Toxicol, Sch Vet Med & Anim Husbrandy, Botucatu, SP, Brazil-
dc.description.affiliationUniv Oeste Paulista, Univ Western São Paulo, Dept Small Anim Clin, Presidente Prudente, SP, Brazil-
dc.description.affiliationCESUMAR, Maringa Univ Ctr, Maringa, Parana, Brazil-
dc.description.affiliationUnespSão Paulo State Univ UNESP, Dept Small Anim Med Clin & Toxicol, Sch Vet Med & Anim Husbrandy, Botucatu, SP, Brazil-
dc.identifier.scieloS1678-91992008000100007-
dc.identifier.wosWOS:000254511600007-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileS1678-91992008000100007.pdf-
dc.relation.ispartofJournal of Venomous Animals and Toxins Including Tropical Diseases-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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