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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/41935
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dc.contributor.authorBrito, S. V.-
dc.contributor.authorSales, D. L.-
dc.contributor.authorCosta, J. G. M.-
dc.contributor.authorRodrigues, F. F. G.-
dc.contributor.authorFerreira, F. S.-
dc.contributor.authorAngelico, E. C.-
dc.contributor.authorCarvalho, J. E.-
dc.contributor.authorAlmeida, W. O.-
dc.contributor.authorAnjos, L. A.-
dc.contributor.authorCoutinho, H. D. M.-
dc.date.accessioned2014-05-20T15:33:15Z-
dc.date.accessioned2016-10-25T18:09:46Z-
dc.date.available2014-05-20T15:33:15Z-
dc.date.available2016-10-25T18:09:46Z-
dc.date.issued2012-08-01-
dc.identifierhttp://dx.doi.org/10.3109/13880209.2012.655858-
dc.identifier.citationPharmaceutical Biology. London: Informa Healthcare, v. 50, n. 8, p. 1026-1030, 2012.-
dc.identifier.issn1388-0209-
dc.identifier.urihttp://hdl.handle.net/11449/41935-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/41935-
dc.description.abstractContext: Amphibian skins have wide variety of biologically active compounds associated with the natural defenses of these animals.Objectives: To study the in vitro anticancer activity of methanol extracts of the skin of Rhinella jimi Stevaux (Anura: Bufonidae).Material and methods: The extract was obtained by cold methanol extraction for 96 h using dried skins (295 mg). The methanol skin extract was dried under reduced pressure, giving a 5.5% yield. In order to test for growth-inhibitory activity, in vitro tests were performed with the following cancer cell lines using concentrations ranging between 0.25-250 mu g/mL of the extract by 48 h: K562 (leukemia), MCF-7 (breast), NCI-ADR (breast with MDR phenotype), UACC-62 (melanoma), NCI460 (lung), PCO3 (prostate), HT-29 (colon), OVCAR (ovary), and 786-0 (kidney).Results: The methanol extract of R. jimi produced a growth inhibition in a dose-dependent manner against the most of the assayed cell lines. In addition to the growth inhibition, the extract induced the cell death in the ovary and colon lines (EC50 0.125 and 0.2 mu g/mL, respectively), demonstrating 100% of inhibition with 2.5 mu g/mL. However, prostate and leukemia cell lines demonstrated less sensitivity, with EC50 of 24 and 235 mu g/mL, respectively. This is the first report about the anticancer activity by natural products from the skin of R. jimi.Conclusions: The methanol extracts of R. jimi significantly affected the growth of several cell lines, demonstrating that these compounds are a potential source of substances that could be utilized in cancer treatments.en
dc.description.sponsorshipFundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico (FUNCAP)-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.description.sponsorshipInstituto Brasileiro do Meio Ambiente e dos Recursos Naturais Renováveis (IBAMA)-
dc.format.extent1026-1030-
dc.language.isoeng-
dc.publisherInforma Healthcare-
dc.sourceWeb of Science-
dc.subjectAmphibiansen
dc.subjectspecial metabolitesen
dc.subjectbiodrugsen
dc.subjectbiodiversity conservationen
dc.subjectanticancer activityen
dc.titleInvestigation of the cytocidal potential of Rhinella jimi skin methanol extractsen
dc.typeoutro-
dc.contributor.institutionUniversidade Federal da Paraíba (UFPB)-
dc.contributor.institutionUniv Reg Cariri URCA-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniversidade Federal da Paraíba (UFPB), Joao Pessoa, PB, Brazil-
dc.description.affiliationUniv Reg Cariri URCA, Crato, CE, Brazil-
dc.description.affiliationUniv Estadual Campinas UNICAMP, Campinas, SP, Brazil-
dc.description.affiliationUniv Estadual Paulista UNESP, Botucatu, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Botucatu, SP, Brazil-
dc.description.sponsorshipIdFUNCAP: 0006-00/2006-
dc.description.sponsorshipIdFUNCAP: 9913/06-
dc.description.sponsorshipIdIBAMA: 066/06-COFAN IBAMA/RAN/02007.001009/04-37-
dc.identifier.doi10.3109/13880209.2012.655858-
dc.identifier.wosWOS:000306191700012-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofPharmaceutical Biology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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