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dc.contributor.authorGuilherme, Luciana R.-
dc.contributor.authorMassabni, Antonio C.-
dc.contributor.authorCuin, Alexandre-
dc.contributor.authorOliveira, Luiz A. A.-
dc.contributor.authorCastellano, Eduardo E.-
dc.contributor.authorHeinrich, Tassiele A.-
dc.contributor.authorCosta-Neto, Claudio M.-
dc.identifier.citationJournal of Coordination Chemistry. Abingdon: Taylor & Francis Ltd, v. 62, n. 10, p. 1561-1571, 2009.-
dc.description.abstractSynthesis, characterization, crystal structure, and biological studies of two complexes with glycolic acid are described. The solid complexes were formulated as K2[VO(C2H2O3)(C2H3O3)2] H2O (1) and K2[{VO2(C2H2O3)}2] (2) and characterized by X-ray studies, Fourier transform infrared spectroscopy (FTIR), Electron paramagnetic resonance (EPR), and magnetic susceptibility. Conversion of 1 to 2 was studied in aqueous solution by UV-Vis spectroscopy and in the solid state by diffuse reflectance spectroscopy. Complex 2 contains dinuclear [{VO2(C2H2O3)}2]2- anions in which glycolate(2-) is a five-membered chelating ring formed by carboxylate and -hydroxy groups. The geometry around the vanadium in 2 was interpreted as intermediate between a trigonal bipyramid and a square pyramid. Vanadium(IV) is pentacoordinate in 1 as a distorted square pyramid. Complex 1 contains a vanadyl group (V=O) surrounded by two oxygens from deprotonated carboxylate and hydroxy groups forming a five-membered ring. Two oxygens from different glycolates(1-) are bonded to the (V=O) also. Biological analysis for potential cytotoxic effects of 1 was performed using Human Cervix Adenocarcinoma (HeLa) cells, a human cervix adenocarcinoma-derived cell line. After incubation for 48 h, 1 causes 90 and 95% of HeLa cells death at 20 and 200 mol L-1, respectively.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.publisherTaylor & Francis Ltd-
dc.sourceWeb of Science-
dc.subjectCrystal structureen
dc.titleSynthesis, characterization, crystal structure, and biological studies of vanadium complexes with glycolic aciden
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.description.affiliationUniv Estadual Paulista, Inst Quim Araraquara, Araraquara, SP, Brazil-
dc.description.affiliationUniv São Paulo, Inst Fis São Carlos, São Carlos, SP, Brazil-
dc.description.affiliationUniv São Paulo, Fac Med Ribeirao Preto, Ribeirao Preto, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim Araraquara, Araraquara, SP, Brazil-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Coordination Chemistry-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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