You are in the accessibility menu

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/42556
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMelo, Fernando L.-
dc.contributor.authorBenati, Fabricio J.-
dc.contributor.authorRoman, Walter Antonio-
dc.contributor.authorPalazzo de Mello, Joao Carlos-
dc.contributor.authorNozawa, Carlos-
dc.contributor.authorCarvalho Linhares, Rosa Elisa-
dc.date.accessioned2014-05-20T15:34:30Z-
dc.date.accessioned2016-10-25T18:10:57Z-
dc.date.available2014-05-20T15:34:30Z-
dc.date.available2016-10-25T18:10:57Z-
dc.date.issued2008-01-01-
dc.identifierhttp://dx.doi.org/10.1016/j.micres.2006.03.011-
dc.identifier.citationMicrobiological Research. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 163, n. 2, p. 136-139, 2008.-
dc.identifier.issn0944-5013-
dc.identifier.urihttp://hdl.handle.net/11449/42556-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/42556-
dc.description.abstractWe investigated the antiviral activity of an aliphatic nitro compound (NC) isolated from Heteropteris aphrodisiaca O. Mach. (Malpighiaceae), a Brazilian medicinal ptant. The NC was tested for its antiviral activity against poliovirus type 1 (PV-1) and bovine herpes virus type 1 (BHV-1) by plaque reduction assay in cell culture. The NC showed a moderate antiviral activity against PV-1 and BHV-1 in HEp-2 celts, and the 50% inhibitory concentration (IC50) were 22.01 mu g/ml (selectivity index (SI) = 2.83) and 21.10 mu g/mi (SI = 2.95), respectivety. At the highest concentration of the drug (40 mu g/ml) a reduction of approximately 80% in plaque assay was observed for both viruses. The treatment of cells or virus prior to infection did not inhibit the replication of virus strains. (C) 2006 Elsevier GmbH. All rights reserved.en
dc.format.extent136-139-
dc.language.isoeng-
dc.publisherElsevier Gmbh, Urban & Fischer Verlag-
dc.sourceWeb of Science-
dc.subjectHeteropteris ophrodisiacaen
dc.subjectaliphatic nitro compounden
dc.subjectpoliovirusen
dc.subjectantiviral activityen
dc.subjectbovine herpesvirusen
dc.titleThe in vitro antiviral activity of an aliphatic nitro compound from Heteropteris aphrodisiacaen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Estadual de Maringá (UEM)-
dc.description.affiliationUniversidade Estadual de Londrina (UEL), Dept Microbiol CCB, BR-86051990 Londrina, Parana, Brazil-
dc.description.affiliationUniv Estadual Paulista, PPG Ciencias Farmaceut, Araraquara, SP, Brazil-
dc.description.affiliationUniversidade Estadual de Maringá (UEM), Dept Farm & Farmacol, Maringa, Parana, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, PPG Ciencias Farmaceut, Araraquara, SP, Brazil-
dc.identifier.doi10.1016/j.micres.2006.03.011-
dc.identifier.wosWOS:000254531400003-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileWOS000254531400003.pdf-
dc.relation.ispartofMicrobiological Research-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.
Show simple item record Show full item record   View Statistics
 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.