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Cold-acclimation improves cold-tolerance of diabetic rats
  • Universidade Estadual Paulista (UNESP)
  • Universidade de São Paulo (USP)
1. 1. The aim of these experiments was to study the extent to which previous cold-acclimation improves the cold-tolerance of diabetic rats. 2. 2. Alloxan diabetic rats (fasting blood glucose higher than 200mg/dl) were used in the experiments. 3. 3. In Expt. 1, non-cold-acclimated control and diabetic rats were exposed to cold environment (7-9°C), and the percentage of survival calculated during a 12-day experimental period. In Expt. 2, the rats were previously cold-acelimated before alloxan or saline injection (diabetic and control cold-acclimated rats) and the survival rate was also assessed during a 12-day period in the cold. 4. 4. The percentage of survival of the non-cold-acclimated diabetic rats (Expt.l) was 19% compared with 79% of the diabetic cold-acclimated animals (Expt. 2). There were no deaths in the control groups. 5. 5. Cold-acclimated diabetic rats maintained a near-normal thermogenic response after noradrenaline injection. This response was impaired in non-cold-acclimated diabetic rats. 6. 6. The results of these experiments suggest that the enhanced cold-tolerance of diabetic cold-acclimated rats could be related to the increased sympathetic activity and enhanced insulin sensitivity in thermogenic tissues, such as brown fat. © 1987.
Issue Date: 
Comparative Biochemistry and Physiology -- Part A: Physiology, v. 88, n. 3, p. 425-429, 1987.
Time Duration: 
  • noradrenalin
  • acclimatization
  • animal
  • body weight
  • cold
  • comparative study
  • drug effect
  • experimental diabetes mellitus
  • male
  • pathophysiology
  • rat
  • rat strain
  • reference value
  • thermoregulation
  • time
  • Acclimatization
  • Animal
  • Body Temperature Regulation
  • Body Weight
  • Cold
  • Comparative Study
  • Diabetes Mellitus, Experimental
  • Male
  • Norepinephrine
  • Rats
  • Rats, Inbred Strains
  • Reference Values
  • Support, Non-U.S. Gov't
  • Time Factors
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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