Please use this identifier to cite or link to this item:
http://acervodigital.unesp.br/handle/11449/63815
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ferro, Jesus A | - |
dc.contributor.author | Macari, Marcos | - |
dc.contributor.author | Eizirik, Décio L | - |
dc.date.accessioned | 2014-05-27T03:15:39Z | - |
dc.date.accessioned | 2016-10-25T18:12:11Z | - |
dc.date.available | 2014-05-27T03:15:39Z | - |
dc.date.available | 2016-10-25T18:12:11Z | - |
dc.date.issued | 1987-12-01 | - |
dc.identifier | http://dx.doi.org/10.1016/0300-9629(87)90057-0 | - |
dc.identifier.citation | Comparative Biochemistry and Physiology -- Part A: Physiology, v. 88, n. 3, p. 425-429, 1987. | - |
dc.identifier.issn | 0300-9629 | - |
dc.identifier.uri | http://hdl.handle.net/11449/63815 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/63815 | - |
dc.description.abstract | 1. 1. The aim of these experiments was to study the extent to which previous cold-acclimation improves the cold-tolerance of diabetic rats. 2. 2. Alloxan diabetic rats (fasting blood glucose higher than 200mg/dl) were used in the experiments. 3. 3. In Expt. 1, non-cold-acclimated control and diabetic rats were exposed to cold environment (7-9°C), and the percentage of survival calculated during a 12-day experimental period. In Expt. 2, the rats were previously cold-acelimated before alloxan or saline injection (diabetic and control cold-acclimated rats) and the survival rate was also assessed during a 12-day period in the cold. 4. 4. The percentage of survival of the non-cold-acclimated diabetic rats (Expt.l) was 19% compared with 79% of the diabetic cold-acclimated animals (Expt. 2). There were no deaths in the control groups. 5. 5. Cold-acclimated diabetic rats maintained a near-normal thermogenic response after noradrenaline injection. This response was impaired in non-cold-acclimated diabetic rats. 6. 6. The results of these experiments suggest that the enhanced cold-tolerance of diabetic cold-acclimated rats could be related to the increased sympathetic activity and enhanced insulin sensitivity in thermogenic tissues, such as brown fat. © 1987. | en |
dc.format.extent | 425-429 | - |
dc.language.iso | eng | - |
dc.source | Scopus | - |
dc.subject | noradrenalin | - |
dc.subject | acclimatization | - |
dc.subject | animal | - |
dc.subject | body weight | - |
dc.subject | cold | - |
dc.subject | comparative study | - |
dc.subject | drug effect | - |
dc.subject | experimental diabetes mellitus | - |
dc.subject | male | - |
dc.subject | pathophysiology | - |
dc.subject | rat | - |
dc.subject | rat strain | - |
dc.subject | reference value | - |
dc.subject | thermoregulation | - |
dc.subject | time | - |
dc.subject | Acclimatization | - |
dc.subject | Animal | - |
dc.subject | Body Temperature Regulation | - |
dc.subject | Body Weight | - |
dc.subject | Cold | - |
dc.subject | Comparative Study | - |
dc.subject | Diabetes Mellitus, Experimental | - |
dc.subject | Male | - |
dc.subject | Norepinephrine | - |
dc.subject | Rats | - |
dc.subject | Rats, Inbred Strains | - |
dc.subject | Reference Values | - |
dc.subject | Support, Non-U.S. Gov't | - |
dc.subject | Time Factors | - |
dc.title | Cold-acclimation improves cold-tolerance of diabetic rats | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Universidade de São Paulo (USP) | - |
dc.description.affiliation | Departamento de Clínicia Médica Faculdade de Medicina de Ribeirão Preto USP, SP | - |
dc.identifier.doi | 10.1016/0300-9629(87)90057-0 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Comparative Biochemistry and Physiology Part A: Physiology | - |
dc.identifier.scopus | 2-s2.0-0023505275 | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.