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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/64248
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dc.contributor.authorSilva, A. E.-
dc.contributor.authorManzato, A. J.-
dc.contributor.authorVarella-Garcia, M.-
dc.date.accessioned2014-05-27T11:17:28Z-
dc.date.accessioned2016-10-25T18:12:56Z-
dc.date.available2014-05-27T11:17:28Z-
dc.date.available2016-10-25T18:12:56Z-
dc.date.issued1992-07-02-
dc.identifierhttp://dx.doi.org/10.1016/0165-7992(92)90098-3-
dc.identifier.citationMutation Research - Mutation Research Letters, v. 282, n. 3, p. 213-217, 1992.-
dc.identifier.issn0165-7992-
dc.identifier.urihttp://hdl.handle.net/11449/64248-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/64248-
dc.description.abstractIn order to investigate the effect of folate depletion, lymphocyte sister-chromatid exchange (SCE) rates were compared among homozygous β-thalassaemic patients with low folic acid levels, heterozygous β-thalassaemic patients with normal folate levels and healthy persons with normal haemoglobin, in cultures with both normal and depleted folate conditions. Significantly higher SCE rates were found in homozygous patients in all assays, but the in vitro folate depletion did not induce an increase in SCE frequency in any group.en
dc.format.extent213-217-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectβ-Thalassaemia-
dc.subjectCulture conditions-
dc.subjectFollic acid-
dc.subjectSister-chromatid exchange-
dc.subjectfolic acid-
dc.subjectbeta thalassemia-
dc.subjectclinical article-
dc.subjectcontrolled study-
dc.subjectheterozygote-
dc.subjecthomozygote-
dc.subjecthuman-
dc.subjecthuman cell-
dc.subjectlymphocyte culture-
dc.subjectpriority journal-
dc.subjectsister chromatid exchange-
dc.subjectAdolescent-
dc.subjectAdult-
dc.subjectAnalysis of Variance-
dc.subjectCells, Cultured-
dc.subjectChild-
dc.subjectChild, Preschool-
dc.subjectFolic Acid Deficiency-
dc.subjectHuman-
dc.subjectInfant-
dc.subjectLymphocytes-
dc.subjectSister Chromatid Exchange-
dc.subjectSupport, Non-U.S. Gov't-
dc.subjectThalassemia-
dc.titleSister-chromatid exchanges in β-thalassaemic patients under conditions of in vivo and in vitro depletion of folic aciden
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDepartamento de Biologia Instituto de Biociencias Letras e Ciencias Exatas, UNESP, Caixa Postal 136, 15055 Sao Jose do Rio Preto, SP-
dc.description.affiliationUnespDepartamento de Biologia Instituto de Biociencias Letras e Ciencias Exatas, UNESP, Caixa Postal 136, 15055 Sao Jose do Rio Preto, SP-
dc.identifier.doi10.1016/0165-7992(92)90098-3-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofMutation Research - Mutation Research Letters-
dc.identifier.scopus2-s2.0-0026740527-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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