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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/64338
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dc.contributor.authorFonseca, Luiz Marcos da-
dc.contributor.authorBrunetti, Iguatemy Lourenço-
dc.contributor.authorRego, E. M.-
dc.contributor.authorGarcia, A. B.-
dc.contributor.authorCilento, G.-
dc.contributor.authorFalcao, R. P.-
dc.date.accessioned2014-05-27T11:17:30Z-
dc.date.accessioned2016-10-25T18:13:04Z-
dc.date.available2014-05-27T11:17:30Z-
dc.date.available2016-10-25T18:13:04Z-
dc.date.issued1993-01-01-
dc.identifierhttp://dx.doi.org/10.1159/000204367-
dc.identifier.citationActa Haematologica, v. 90, n. 1, p. 19-24, 1993.-
dc.identifier.issn0001-5792-
dc.identifier.urihttp://hdl.handle.net/11449/64338-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/64338-
dc.description.abstractA simple and sensitive chemiluminescence assay for the demonstration of the activity of intracellular myeloperoxidase (MPO) is described, which is useful for the distinction between myeloid and lymphoid commitment in blasts from acute leukemia patients. When the cut-off point was settled at 13 mV of chemiluminescence all cases of acute myeloid leukemia (AML) were distinguished from those of acute lymphoid leukemia. In addition, this technique was able to demonstrate MPO activity in AML poorly differentiated (FAB-M0) which usually does not stain for MPO in classical cytochemistry preparations and could be negative also by immunocytochemistry with anti-MPO monoclonal antibody. Therefore the method here described presented a higher sensitivity than the immunocytochemistry procedure with anti-MPO.en
dc.format.extent19-24-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectAcute leukemia-
dc.subjectAntimyeloperoxidase-
dc.subjectChemiluminescence-
dc.subjectMyeloperoxidase-
dc.subjectmyeloperoxidase-
dc.subjectacute granulocytic leukemia-
dc.subjectacute lymphocytic leukemia-
dc.subjectadolescent-
dc.subjectadult-
dc.subjectaged-
dc.subjectbone marrow biopsy-
dc.subjectchemoluminescence-
dc.subjectchild-
dc.subjectcontrolled study-
dc.subjectdiagnostic accuracy-
dc.subjectenzyme activity-
dc.subjecthuman-
dc.subjecthuman tissue-
dc.subjectimmunocytochemistry-
dc.subjectinfant-
dc.subjectintermethod comparison-
dc.subjectmajor clinical study-
dc.subjectpriority journal-
dc.subjectAcute Disease-
dc.subjectAdolescent-
dc.subjectAdult-
dc.subjectAged-
dc.subjectAged, 80 and over-
dc.subjectAntibodies, Monoclonal-
dc.subjectChild-
dc.subjectChild, Preschool-
dc.subjectComparative Study-
dc.subjectDiagnosis, Differential-
dc.subjectHuman-
dc.subjectImmunohistochemistry-
dc.subjectImmunophenotyping-
dc.subjectInfant-
dc.subjectLeukemia, Lymphocytic, Acute-
dc.subjectLeukemia, Myeloid-
dc.subjectMiddle Age-
dc.subjectPeroxidase-
dc.subjectSensitivity and Specificity-
dc.subjectSupport, Non-U.S. Gov't-
dc.titleCharacterization of myeloid or lymphoid acute leukemia by a chemiluminescence assay: Comparison with immunocytochemistry using an antimyeloperoxidase antibodyen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDepartment of Clinical Analysis Faculty of Pharmaceutical Sciences UNESP, Rue Expedicionarios do Brasil 1621, Araraquara, SP 14801-902-
dc.description.affiliationUnespDepartment of Clinical Analysis Faculty of Pharmaceutical Sciences UNESP, Rue Expedicionarios do Brasil 1621, Araraquara, SP 14801-902-
dc.identifier.doi10.1159/000204367-
dc.identifier.wosWOS:A1993MH30300005-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofActa Haematologica-
dc.identifier.scopus2-s2.0-0027484569-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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