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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/64629
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dc.contributor.authorVelasco-Cornejo, I. F.-
dc.contributor.authorCuadrado Martin, L.-
dc.contributor.authorDa Silva Franco, R. J.-
dc.date.accessioned2014-05-27T11:18:01Z-
dc.date.accessioned2016-10-25T18:13:34Z-
dc.date.available2014-05-27T11:18:01Z-
dc.date.available2016-10-25T18:13:34Z-
dc.date.issued1995-08-09-
dc.identifierhttp://www.arquivosonline.com.br/pesquisartigos/Pdfs/1995/V64N6/64060014.pdf-
dc.identifier.citationArquivos Brasileiros de Cardiologia, v. 64, n. 6, p. 571-575, 1995.-
dc.identifier.issn0066-782X-
dc.identifier.urihttp://hdl.handle.net/11449/64629-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/64629-
dc.description.abstractPurpose. To evaluate the antihypertensive efficacy and tolerability of captopril 50 mg + hydrochlorothiazide 25 mg daily in mild to moderate primary hypertension. Methods. Out-patients (n = 471) with mild to moderate hypertension, diastolic blood pressure (DBP) 95-115 mmHg, with 15 days of washout, were included to the treatment initially with half tablet of the association of captopril 50 mg + hydrochlorothiazide 25 mg once daily, for 30 days. After this period, patients with DBP > 90 mmHg had the dosage duplicated, while the others had the same dosage for 60 days more. Evaluation was performed 15 days before and then every month during active drug. Results. Twenty six patients were withdrawn, 13 (2,7%) by adverse effects and 13 by protocol violation. At the end of the wash-out period, the blood pressure (BP), 162 ± 16/103 ± 6 mmHg decreased significantly at the 30th day to 146 ± 14/92 ± 8 mmHg (p < 0,001 vs 0th day); 139 ± 12/86 ± 7 mmHg at the 60th day, (p < 0,001 vs 30th day), and further to 136 ± 11/84 ± 5 mmHg (p < 0,001 vs day 0) till the end of the 90th day. Antihypertensive efficay (DBP ≤ 90 mmHg and decreased for the DBP ≥ 10 mmHg) was obtained in 82% of the patients. There was no difference in BP control considering race, hypertension level, previous antihypertensive treatment and obesity. Cough (4%) was the main adverse event. Conclusion. Captopril + hydrochlorothiazide was effective and safe in the treatment of mild to moderate hypertension. The favorable response was observed in 82% of the patients independently of race, hypertensive level, previous antihypertensive treatment and obesity. Low incidence of side effects was reported, with no difference from others reported in the literature.en
dc.format.extent571-575-
dc.language.isopor-
dc.sourceScopus-
dc.subjectangiotensin converting enzyme inhibitor-
dc.subjectcaptopril-
dc.subjecthydrochlorothiazide-
dc.subjectantihypertensive agent-
dc.subjectadult-
dc.subjectaged-
dc.subjectantihypertensive activity-
dc.subjectblood pressure-
dc.subjectclinical trial-
dc.subjectcontrolled clinical trial-
dc.subjectcontrolled study-
dc.subjectcoughing-
dc.subjectdrug efficacy-
dc.subjectdrug tolerance-
dc.subjectfemale-
dc.subjecthuman-
dc.subjecthypertension-
dc.subjectmajor clinical study-
dc.subjectmale-
dc.subjectoral drug administration-
dc.subjectadolescent-
dc.subjectdrug combination-
dc.subjectdrug effect-
dc.subjectheart rate-
dc.subjecthospitalization-
dc.subjectmiddle aged-
dc.subjectmulticenter study-
dc.subjectAdolescent-
dc.subjectAdult-
dc.subjectAged-
dc.subjectAged, 80 and over-
dc.subjectAntihypertensive Agents-
dc.subjectBlood Pressure-
dc.subjectCaptopril-
dc.subjectDrug Therapy, Combination-
dc.subjectFemale-
dc.subjectHeart Rate-
dc.subjectHumans-
dc.subjectHydrochlorothiazide-
dc.subjectHypertension-
dc.subjectMale-
dc.subjectMiddle Aged-
dc.subjectSeverity of Illness Index-
dc.titleEFICACIA E TOLERABILIDADE DA ASSOCIACAO CAPTOPRIL + HIDROCLOROTIAZIDA NO TRATAMENTO DA HIPERTENSAO ARTERIAL LEVE A MODERADA. ESTUDO MULTICENTRICOpt
dc.title.alternativeEfficacy and tolerability of the association of captopril + hydrochlorothiazide in the treatment of mild-to-moderate hypertension. A multicenter trialen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDept. Clinica Medica Faculdade de Medicina UNESP, CEP 18618-000 Botucatu, SP-
dc.description.affiliationUnespDept. Clinica Medica Faculdade de Medicina UNESP, CEP 18618-000 Botucatu, SP-
dc.rights.accessRightsAcesso aberto-
dc.identifier.file2-s2.0-0029115889.pdf-
dc.relation.ispartofArquivos Brasileiros de Cardiologia-
dc.identifier.scopus2-s2.0-0029115889-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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