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http://acervodigital.unesp.br/handle/11449/64664- Title:
- Bioactive guanidine alkaloids from Pterogyne nitens
- Universidade Estadual Paulista (UNESP)
- VIRGINIA POLYTECH INST & STATE UNIV
- 0163-3864
- Bioactivity-guided fractionation of a methanolic CHCl 3 extract of the leaves of Pterogyne nitens afforded the known guanidine alkaloid pterogynidine [2] and three new guanidine alkaloids, nitensidines A [3], B [4], and C [5], all of which exhibited selective activity towards the DNA repair-deficient yeast mutant RS 321 (IC 12=9.3-20.0 μg/ml); 3,4, and 5 were moderately cytotoxic to CHO Aux B 1 cells (IC 50=8.5-13.0 μg/ml).
- 1-Dec-1995
- Journal of Natural Products, v. 58, n. 11, p. 1683-1688, 1995.
- 1683-1688
- guanidine derivative
- nitensidine
- pterogynidine
- pterogynine
- unclassified drug
- antineoplastic activity
- bioassay
- carbon nuclear magnetic resonance
- cytotoxicity
- dna repair
- drug activity
- drug isolation
- drug structure
- proton nuclear magnetic resonance
- http://dx.doi.org/10.1021/np50125a006
- Acesso restrito
- outro
- http://repositorio.unesp.br/handle/11449/64664
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