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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/64664
Title: 
Bioactive guanidine alkaloids from Pterogyne nitens
Author(s): 
Institution: 
  • Universidade Estadual Paulista (UNESP)
  • VIRGINIA POLYTECH INST & STATE UNIV
ISSN: 
0163-3864
Abstract: 
Bioactivity-guided fractionation of a methanolic CHCl 3 extract of the leaves of Pterogyne nitens afforded the known guanidine alkaloid pterogynidine [2] and three new guanidine alkaloids, nitensidines A [3], B [4], and C [5], all of which exhibited selective activity towards the DNA repair-deficient yeast mutant RS 321 (IC 12=9.3-20.0 μg/ml); 3,4, and 5 were moderately cytotoxic to CHO Aux B 1 cells (IC 50=8.5-13.0 μg/ml).
Issue Date: 
1-Dec-1995
Citation: 
Journal of Natural Products, v. 58, n. 11, p. 1683-1688, 1995.
Time Duration: 
1683-1688
Keywords: 
  • guanidine derivative
  • nitensidine
  • pterogynidine
  • pterogynine
  • unclassified drug
  • antineoplastic activity
  • bioassay
  • carbon nuclear magnetic resonance
  • cytotoxicity
  • dna repair
  • drug activity
  • drug isolation
  • drug structure
  • proton nuclear magnetic resonance
Source: 
http://dx.doi.org/10.1021/np50125a006
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/64664
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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