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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/64664
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dc.contributor.authorBolzani, Vanderlan da Silva-
dc.contributor.authorGunatilaka, A. A. Leslie-
dc.contributor.authorKingston, David G. I.-
dc.date.accessioned2014-05-27T11:18:02Z-
dc.date.accessioned2016-10-25T18:13:38Z-
dc.date.available2014-05-27T11:18:02Z-
dc.date.available2016-10-25T18:13:38Z-
dc.date.issued1995-12-01-
dc.identifierhttp://dx.doi.org/10.1021/np50125a006-
dc.identifier.citationJournal of Natural Products, v. 58, n. 11, p. 1683-1688, 1995.-
dc.identifier.issn0163-3864-
dc.identifier.urihttp://hdl.handle.net/11449/64664-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/64664-
dc.description.abstractBioactivity-guided fractionation of a methanolic CHCl 3 extract of the leaves of Pterogyne nitens afforded the known guanidine alkaloid pterogynidine [2] and three new guanidine alkaloids, nitensidines A [3], B [4], and C [5], all of which exhibited selective activity towards the DNA repair-deficient yeast mutant RS 321 (IC 12=9.3-20.0 μg/ml); 3,4, and 5 were moderately cytotoxic to CHO Aux B 1 cells (IC 50=8.5-13.0 μg/ml).en
dc.format.extent1683-1688-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectguanidine derivative-
dc.subjectnitensidine-
dc.subjectpterogynidine-
dc.subjectpterogynine-
dc.subjectunclassified drug-
dc.subjectantineoplastic activity-
dc.subjectbioassay-
dc.subjectcarbon nuclear magnetic resonance-
dc.subjectcytotoxicity-
dc.subjectdna repair-
dc.subjectdrug activity-
dc.subjectdrug isolation-
dc.subjectdrug structure-
dc.subjectproton nuclear magnetic resonance-
dc.titleBioactive guanidine alkaloids from Pterogyne nitensen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionVIRGINIA POLYTECH INST & STATE UNIV-
dc.description.affiliationDepartment of Chemistry Virginia Polytechnic Institute State University, Blacksburg, VA 24061-0212-
dc.description.affiliationVirginia Polytechnic Institute State University-
dc.description.affiliationInstituto de Quimica Universidade Estadual Paulista, CP. 355, 14800, Araraquara, SP-
dc.description.affiliationUnespInstituto de Quimica Universidade Estadual Paulista, CP. 355, 14800, Araraquara, SP-
dc.identifier.doi10.1021/np50125a006-
dc.identifier.wosWOS:A1995TQ55100006-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Natural Products-
dc.identifier.scopus2-s2.0-0029610979-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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