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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/64725
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dc.contributor.authorGanem, Eliana Marisa-
dc.contributor.authorCastiglia, Yara Marcondes Machado-
dc.contributor.authorVianna, Pedro Thadeu Galvão-
dc.contributor.authorMódolo, Norma Sueli Pinheiro-
dc.contributor.authorBraz, José Reinaldo Cerqueira-
dc.date.accessioned2014-05-27T11:18:03Z-
dc.date.accessioned2016-10-25T18:13:44Z-
dc.date.available2014-05-27T11:18:03Z-
dc.date.available2016-10-25T18:13:44Z-
dc.date.issued1996-01-01-
dc.identifierhttp://www.sba.com.br/arquivos/revista/rba/mar96122.pdf-
dc.identifier.citationRevista Brasileira de Anestesiologia, v. 46, n. 2, p. 122-129, 1996.-
dc.identifier.issn0034-7094-
dc.identifier.urihttp://hdl.handle.net/11449/64725-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/64725-
dc.description.abstractBackground and objectives - The use of magnesium sulphate for the prevention of seizures in pre-eclampsia may induce hypermagnesemia. Clinical and experimental studies are not in agreement about the effects of magnesium on the renal hemodynamics and function. We therefore studied the effects of hypermagnesemia on the renal hemodynamics and function of dogs anesthetized with pentobarbitone. Methods - Sixteen mongrel dogs were anesthetized with pentobarbitone 30 mg.kg-1 and submitted to extracellular ) and mechanical ventilation with room air. The dogs were volume expansion with Ringer's solution (0.4 ml.kg.min allocated into two groups of 8 animals, for the study of renal hemodynamics and function following the administration of 5 mg.kg-1 of pentobarbitone (Group 1 - control or of pentobarbitone associated with magnesium sulphate in the dose (Group 2). The parameters studied were: PAH of 140 mg.kg, administered in 15 minutes, followed by 80 mg.kg-1.h-1 clearance, creatinine clearance, osmolar clearance, free water clearance, renal blood flow, renal vascular resistance, filtration fraction, urinary volume, plasmatic and urinary osmolarity, urinary and fractionary excretion of sodium and potassium, measured at five moments: 15 (M1), 30 (M2), 60 (M3) and 75 (M4) minutes after the first supplementary dose of pentobarbitone and 15 minutes (M5) after the second supplementary dose in Group 1. In Group 2, the moments M3, M4, M5 were 15, 30 and 60 minutes after the priming dose of magnesium sulphate and during the maintenance dose. Results - In Group I no significant changes were observed in renal hemodynamic parameters and creatinine clearance. The extracellular volume expansion increased urinary volume and decreased urinary osmolarity as a consequence of sodium, potassium and free water clearance. The fractionary excretion of sodium was maintained. The plasmatic osmolarity increased. In Group 2, renal hemodynamic parameters and creatinine clearance were also maintained. There was an increase in renal sodium clearance, as detected by the increase in the fractionary excretion of sodium. Conclusions - Magnesium sulphate did not produce significant changes in renal hemodynamics and facilitated the renal excretion of sodium in dogs anesthetized with pentobarbitone.en
dc.format.extent122-129-
dc.language.isospa-
dc.sourceScopus-
dc.subjectAnesthetic tecniques: venous-
dc.subjectAnimal: dog-
dc.subjectDrugs: magnesium sulphate, pentobarbitone-
dc.subjectExperimental anesthesia-
dc.subjectRenal system: function-
dc.subject4 aminohippuric acid-
dc.subjectanticonvulsive agent-
dc.subjectcreatinine-
dc.subjectmagnesium sulfate-
dc.subjectpentobarbital-
dc.subject4 aminohippuric acid clearance-
dc.subjectanimal experiment-
dc.subjectartificial ventilation-
dc.subjectcontrolled study-
dc.subjectcreatinine clearance-
dc.subjectdog-
dc.subjectfree water clearance-
dc.subjectglomerulus filtration-
dc.subjecthypermagnesemia-
dc.subjectkidney blood flow-
dc.subjectkidney function-
dc.subjectkidney vascular resistance-
dc.subjectnonhuman-
dc.subjectosmotic diuresis-
dc.subjectplasma osmolarity-
dc.subjectpotassium urine level-
dc.subjectpreeclampsia-
dc.subjectseizure-
dc.subjectsodium urine level-
dc.subjecturine osmolality-
dc.subjecturine volume-
dc.titleEFEITOS DO SULFATE DE MAGNESIO NA HEMODINAMICA E FUNCAO RENAL DE CAES ANESTESIADOS CORN PENTOBARBITAL SODICOes
dc.title.alternativeEffects of magnesium sulphate on the renal hemodynamics and function of dogs anesthetized with pentobarbitoneen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDepartamento de Anestesiologia Faculdade de Medicina UNESP, Caixa Postal 530, 18618-970-Botucatu-SP-
dc.description.affiliationUnespDepartamento de Anestesiologia Faculdade de Medicina UNESP, Caixa Postal 530, 18618-970-Botucatu-SP-
dc.rights.accessRightsAcesso aberto-
dc.identifier.file2-s2.0-0029967841.pdf-
dc.relation.ispartofRevista Brasileira de Anestesiologia-
dc.identifier.scopus2-s2.0-0029967841-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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