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dc.contributor.authorFracasso, J. F.-
dc.contributor.authorSouza, Ricardo Luiz Nunes de-
dc.identifier.citationRevista de Ciencias Farmaceuticas, v. 17, p. 169-180.-
dc.description.abstractThe effect of intravenous infusion of hypertonic saline (HS) on the recovery of mean arterial pressure (MAP) during septic shock was studied in sham-operated rats and in rats with electrolytic lesion in the anteroventral third ventricle (AV3V) region. Our results show that intravenous HS infusion in rats treated with endotoxin (Etx) partially restores MAP, but when we have a severe shock produced by Etx, HS was not able to reverse the hypotension. We also show that the integrity of the AV3V region is essential for the protective action of HS in endotoxin shock. It is possible that NO production contributes to the deleterious effect of endotoxin. So, the unraveling of the release of NO by the vascular endothelium and their role as regulators of vascular tone is increasing our understanding of the physiology and pathophysiology of the cardiovascular system and will therefore enhance the possibilities of preventing and treating endotoxin shock.en
dc.subject7,5% NaCl-
dc.subjectAV3V lesion and septic shock-
dc.subjecthypertonic saline-
dc.subjectnitric oxide-
dc.subjectsodium chloride-
dc.subjectanimal experiment-
dc.subjectanimal model-
dc.subjectblood pressure-
dc.subjectblood vessel tone-
dc.subjectbrain region-
dc.subjectbrain ventricle-
dc.subjectintracerebroventricular drug administration-
dc.subjectseptic shock-
dc.titlePapel da regiao AV3V no choque septico experimental em ratos tratados com NaCl 7,5%pt
dc.title.alternativeThe role of AV3V region in experimental septic shock in rats treated with NaCl 7,5%en
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDepto. Princip. Ativos Nat./Toxicol. Faculdade de Ciencias Farmaceuticas UNESP, 14801-902 Araraquara, SP-
dc.description.affiliationUnespDepto. Princip. Ativos Nat./Toxicol. Faculdade de Ciencias Farmaceuticas UNESP, 14801-902 Araraquara, SP-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofRevista de Ciencias Farmaceuticas-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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