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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/64827
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dc.contributor.authorCastilho, R. F.-
dc.contributor.authorPereira, R. S.-
dc.contributor.authorVercesi, A. E.-
dc.date.accessioned2014-05-27T11:18:06Z-
dc.date.accessioned2016-10-25T18:13:57Z-
dc.date.available2014-05-27T11:18:06Z-
dc.date.available2016-10-25T18:13:57Z-
dc.date.issued1996-08-07-
dc.identifierhttp://dx.doi.org/10.1007/BF03190273-
dc.identifier.citationEuropean Journal of Drug Metabolism and Pharmacokinetics, v. 21, n. 1, p. 17-21, 1996.-
dc.identifier.issn0378-7966-
dc.identifier.urihttp://hdl.handle.net/11449/64827-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/64827-
dc.description.abstractIn this study, we show that safranine at the concentrations usually employed as a probe of mitochondrial membrane potential significantly protects against the oxidative damage of mitochondria induced by Fe(II)citrate. The effect of safranine was illustrated by experiments showing that this dye strongly inhibits both production of thiobarbituric acid-reactive substances and membrane potential decrease when energized mitochondria were exposed to Fe(II)citrate in the presence of Ca 2+ ions. Similar results were obtained with the lipophylic compound trifluoperazine. It is proposed that, like trifluoperazine, safranine decreases the rate of lipid peroxidation due to its insertion in the membrane altering the physical state of the lipid phase.en
dc.format.extent17-21-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectFe(II)citrate-
dc.subjectMitochondrial damage-
dc.subjectSafranine-
dc.subjectTrifluoperazine-
dc.subjectcalcium ion-
dc.subjectdye-
dc.subjectferric citrate-
dc.subjectsafranin-
dc.subjectthiobarbituric acid reactive substance-
dc.subjecttrifluoperazine-
dc.subjectunclassified drug-
dc.subjectanimal tissue-
dc.subjectcell membrane potential-
dc.subjectcontrolled study-
dc.subjectlipid peroxidation-
dc.subjectliver mitochondrion-
dc.subjectmale-
dc.subjectmembrane damage-
dc.subjectmitochondrial membrane-
dc.subjectnonhuman-
dc.subjectrat-
dc.subjectAnimals-
dc.subjectAntipsychotic Agents-
dc.subjectColoring Agents-
dc.subjectFerrous Compounds-
dc.subjectLipid Peroxidation-
dc.subjectMale-
dc.subjectMembrane Potentials-
dc.subjectMitochondria, Liver-
dc.subjectPhenazines-
dc.subjectRats-
dc.titleProtective effect of safranine on the mitochondrial damage induced by Fe(II)citrate: Comparative study with trifluoperazineen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDepartamento de Bioquímica IB UNICAMP, Campinas, São Paulo-
dc.description.affiliationDepartamento de Bioquímica IQ UNESP, Araraquara, São Paulo-
dc.description.affiliationDepartamento de Bioquímica IQ UNESP, Araraquara, SP 14801-970-
dc.description.affiliationUnespDepartamento de Bioquímica IQ UNESP, Araraquara, São Paulo-
dc.description.affiliationUnespDepartamento de Bioquímica IQ UNESP, Araraquara, SP 14801-970-
dc.identifier.doi10.1007/BF03190273-
dc.identifier.wosWOS:A1996UY20800004-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofEuropean Journal of Drug Metabolism and Pharmacokinetics-
dc.identifier.scopus2-s2.0-0030036239-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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