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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/64878
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dc.contributor.authorVanderlei, L. C M-
dc.contributor.authorMarcondes, F. K.-
dc.contributor.authorLanza, L. L B-
dc.contributor.authorSpadari-Bratfisch, R. C.-
dc.date.accessioned2014-05-27T11:18:07Z-
dc.date.accessioned2016-10-25T18:14:02Z-
dc.date.available2014-05-27T11:18:07Z-
dc.date.available2016-10-25T18:14:02Z-
dc.date.issued1996-11-23-
dc.identifierhttp://dx.doi.org/10.1139/cjpp-74-6-670-
dc.identifier.citationCanadian Journal of Physiology and Pharmacology, v. 74, n. 6, p. 670-678, 1996.-
dc.identifier.issn0008-4212-
dc.identifier.urihttp://hdl.handle.net/11449/64878-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/64878-
dc.description.abstractWe investigated the mechanisms of the alterations in sensitivity to catecholamines in right atria from female rats exhibiting regular 4-day estrous cycles after three foot-shock sessions at estrus, metestrus, and diestrus or at diestrus, proestrus, and estrus. Right atria from stressed rats sacrificed at diestrus showed subsensitivity to noradrenaline and adrenaline. After in vitro sympathetic denervation (38 μM 6-hydroxydopamine) plus inhibition of neuronal reuptake (0.1 μM desipramine) subsensitivity to noradrenaline was abolished, but it was again evident when extraneuronal uptake was also inhibited (10 μM phenoxybenzamine and 30 μM corticosterone). The same pretreatment abolished the subsensitivity to adrenaline. After addition of 1 μM butoxamine, a β2-adrenoceptor antagonist, the tissues from stressed rats were subsensitive to adrenaline. Right atria from stressed rats sacrificed at estrus did not show any alteration in sensitivity to catecholamines. We conclude that after foot-shock stress, right atria from female rats sacrificed at diestrus showed subsensitivity of the chronotropic response to catecholamines as a result of a conformational alteration of β1-adrenoceptors, simultaneously with an increase in β2-adrenoceptor-mediated response. The mechanisms seem to be similar to those which underlie stress-induced alterations in catecholamine sensitivity in right atria from male rats. However, during estrus there are some protective factors that prevent the effects of stress on right atria.en
dc.format.extent670-678-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectAdrenaline-
dc.subjectDiestrus-
dc.subjectEstrus-
dc.subjectFemale rats-
dc.subjectFoot-shock stress-
dc.subjectNoradrenaline-
dc.subjectSubsensitivity-
dc.subjectadrenalin-
dc.subjectbutoxamine-
dc.subjectcatecholamine derivative-
dc.subjectcorticosterone-
dc.subjectdesipramine-
dc.subjectnoradrenalin-
dc.subjectoxidopamine-
dc.subjectphenoxybenzamine-
dc.subjectanimal experiment-
dc.subjectanimal tissue-
dc.subjectchronotropism-
dc.subjectcontrolled study-
dc.subjectdenervation-
dc.subjectdiestrus-
dc.subjectdrug sensitivity-
dc.subjectestrus cycle-
dc.subjectfemale-
dc.subjectheart right atrium-
dc.subjectin vitro study-
dc.subjectnonhuman-
dc.subjectpriority journal-
dc.subjectrat-
dc.subjectstress-
dc.subjectAdrenergic beta-Antagonists-
dc.subjectAnimals-
dc.subjectAtrial Function-
dc.subjectButoxamine-
dc.subjectElectroshock-
dc.subjectEpinephrine-
dc.subjectFemale-
dc.subjectHeart Atria-
dc.subjectHeart Rate-
dc.subjectNorepinephrine-
dc.subjectRats-
dc.subjectRats, Wistar-
dc.subjectStress-
dc.titleInfluence of the estrous cycle on the sensitivity to catecholamines in right atria from rats submitted to foot-shock stressen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.description.affiliationDepartamento de Fisioterapia Faculdade de Cie. e Tecnologia Universidade Estadual Paulista, Presidente Prudente, São Paulo-
dc.description.affiliationDepto. de Fisiol. e Biofísica Instituto de Biologia Universidade Estadual de Campinas, Campinas, São Paulo-
dc.description.affiliationDentistry Graduate Program Faculdade de Odontol. de Piracicaba Universidade Estadual de Campinas, Piracicaba, São Paulo-
dc.description.affiliationDepto. de Fisiol. e Biofísica Instituto de Biologia UNICAMP, 13081-970, Campinas, São Paulo-
dc.description.affiliationUnespDepartamento de Fisioterapia Faculdade de Cie. e Tecnologia Universidade Estadual Paulista, Presidente Prudente, São Paulo-
dc.identifier.doi10.1139/cjpp-74-6-670-
dc.identifier.wosWOS:A1996VP80100008-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofCanadian Journal of Physiology and Pharmacology-
dc.identifier.scopus2-s2.0-0029819914-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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