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Assessment of vitamin A status in chronic obstructive pulmonary disease patients and healthy smokers
  • Universidade de São Paulo (USP)
  • Universidade Estadual Paulista (UNESP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
The relation between vitamin A status and the degree of lung airway obstruction was examined in a cross-sectional study of 36 male subjects aged 43-74 y who were assigned to five groups as follows: healthy nonsmokers (n = 7), healthy smokers (n = 7), mild chronic obstructive pulmonary disease (COPD-mild) patients (n = 9), COPD-moderate-severe patients (n = 7), and COPD-moderate-severe patients with exacerbation (+ex; n = 6). Smoking habits, pulmonary function tests, and energy-protein status were assessed; serum concentrations of retinyl esters, retinol, retinol binding protein, and transthyretin and relative dose responses were measured. In addition, 12 male smokers aged 45-61 y with mild COPD were randomly assigned to two groups for a longitudinal study: six subjects consumed vitamin A (1000 RE/d; COPD- vitamin A) and six subjects received placebo for 30 d. Lowered serum retinol concentrations were found in the COPD-moderate-severe and COPD-moderate- severe+ex groups. Measurements of vitamin A status in healthy smokers and in COPD-mild patients were not different from those in healthy nonsmokers. The improvement of pulmonary function test results after vitamin A supplementation [mean increase for 1-s forced expiratory volume (FEV1) = 22.9% in the COPD-vitamin A group] may support the assumption of a local (respiratory) vitamin A deficiency in patients with this disease.
Issue Date: 
American Journal of Clinical Nutrition, v. 64, n. 6, p. 928-934, 1996.
Time Duration: 
  • chronic obstructive pulmonary disease
  • pulmonary function tests
  • retinol circulating complex
  • Vitamin A status assessment
  • acute phase protein
  • albumin
  • alpha carotene
  • beta carotene
  • c reactive protein
  • ceruloplasmin
  • placebo
  • prealbumin
  • retinol binding protein
  • retinol ester
  • retinol palmitate
  • airway obstruction
  • chronic obstructive lung disease
  • cigarette smoking
  • clinical protocol
  • clinical trial
  • controlled clinical trial
  • controlled study
  • diet supplementation
  • disease severity
  • forced expiratory volume
  • lung function test
  • nutritional status
  • oral drug administration
  • randomized controlled trial
  • retinol deficiency
  • vitamin blood level
  • Analysis of Variance
  • Carotenoids
  • Cross-Sectional Studies
  • Diet
  • Intestinal Absorption
  • Liver
  • Longitudinal Studies
  • Lung
  • Lung Diseases, Obstructive
  • Middle Aged
  • Nutritional Status
  • Respiratory Function Tests
  • Smoking
  • Vitamin A
  • Vitamin A Deficiency
Access Rights: 
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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