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dc.contributor.authorPaiva, Sergio Alberto Rupp de-
dc.contributor.authorGodoy, Irma de-
dc.contributor.authorVannucchi, Hélio-
dc.contributor.authorFávaro, Rosa M. D.-
dc.contributor.authorGeraldo, Rosana R. C.-
dc.contributor.authorCampana, Alvaro O.-
dc.identifier.citationAmerican Journal of Clinical Nutrition, v. 64, n. 6, p. 928-934, 1996.-
dc.description.abstractThe relation between vitamin A status and the degree of lung airway obstruction was examined in a cross-sectional study of 36 male subjects aged 43-74 y who were assigned to five groups as follows: healthy nonsmokers (n = 7), healthy smokers (n = 7), mild chronic obstructive pulmonary disease (COPD-mild) patients (n = 9), COPD-moderate-severe patients (n = 7), and COPD-moderate-severe patients with exacerbation (+ex; n = 6). Smoking habits, pulmonary function tests, and energy-protein status were assessed; serum concentrations of retinyl esters, retinol, retinol binding protein, and transthyretin and relative dose responses were measured. In addition, 12 male smokers aged 45-61 y with mild COPD were randomly assigned to two groups for a longitudinal study: six subjects consumed vitamin A (1000 RE/d; COPD- vitamin A) and six subjects received placebo for 30 d. Lowered serum retinol concentrations were found in the COPD-moderate-severe and COPD-moderate- severe+ex groups. Measurements of vitamin A status in healthy smokers and in COPD-mild patients were not different from those in healthy nonsmokers. The improvement of pulmonary function test results after vitamin A supplementation [mean increase for 1-s forced expiratory volume (FEV1) = 22.9% in the COPD-vitamin A group] may support the assumption of a local (respiratory) vitamin A deficiency in patients with this disease.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.subjectchronic obstructive pulmonary disease-
dc.subjectpulmonary function tests-
dc.subjectretinol circulating complex-
dc.subjectVitamin A status assessment-
dc.subjectacute phase protein-
dc.subjectalpha carotene-
dc.subjectbeta carotene-
dc.subjectc reactive protein-
dc.subjectretinol binding protein-
dc.subjectretinol ester-
dc.subjectretinol palmitate-
dc.subjectairway obstruction-
dc.subjectchronic obstructive lung disease-
dc.subjectcigarette smoking-
dc.subjectclinical protocol-
dc.subjectclinical trial-
dc.subjectcontrolled clinical trial-
dc.subjectcontrolled study-
dc.subjectdiet supplementation-
dc.subjectdisease severity-
dc.subjectforced expiratory volume-
dc.subjectlung function test-
dc.subjectnutritional status-
dc.subjectoral drug administration-
dc.subjectrandomized controlled trial-
dc.subjectretinol deficiency-
dc.subjectvitamin blood level-
dc.subjectAnalysis of Variance-
dc.subjectCross-Sectional Studies-
dc.subjectIntestinal Absorption-
dc.subjectLongitudinal Studies-
dc.subjectLung Diseases, Obstructive-
dc.subjectMiddle Aged-
dc.subjectNutritional Status-
dc.subjectRespiratory Function Tests-
dc.subjectVitamin A-
dc.subjectVitamin A Deficiency-
dc.titleAssessment of vitamin A status in chronic obstructive pulmonary disease patients and healthy smokersen
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDepartment of Internal Medicine Faculty of Medicine of Botucatu, 18618-000, Botucatu, SP-
dc.description.affiliationUnespDepartment of Internal Medicine, Faculty of Medicine of Botucatu UNESP, Brazil.-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofAmerican Journal of Clinical Nutrition-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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