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DC Field | Value | Language |
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dc.contributor.author | Paiva, Sergio Alberto Rupp de | - |
dc.contributor.author | Godoy, Irma de | - |
dc.contributor.author | Vannucchi, Hélio | - |
dc.contributor.author | Fávaro, Rosa M. D. | - |
dc.contributor.author | Geraldo, Rosana R. C. | - |
dc.contributor.author | Campana, Alvaro O. | - |
dc.date.accessioned | 2014-05-27T11:18:07Z | - |
dc.date.accessioned | 2016-10-25T18:14:02Z | - |
dc.date.available | 2014-05-27T11:18:07Z | - |
dc.date.available | 2016-10-25T18:14:02Z | - |
dc.date.issued | 1996-12-01 | - |
dc.identifier | http://ajcn.nutrition.org/content/64/6/928.abstract | - |
dc.identifier.citation | American Journal of Clinical Nutrition, v. 64, n. 6, p. 928-934, 1996. | - |
dc.identifier.issn | 0002-9165 | - |
dc.identifier.uri | http://hdl.handle.net/11449/64880 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/64880 | - |
dc.description.abstract | The relation between vitamin A status and the degree of lung airway obstruction was examined in a cross-sectional study of 36 male subjects aged 43-74 y who were assigned to five groups as follows: healthy nonsmokers (n = 7), healthy smokers (n = 7), mild chronic obstructive pulmonary disease (COPD-mild) patients (n = 9), COPD-moderate-severe patients (n = 7), and COPD-moderate-severe patients with exacerbation (+ex; n = 6). Smoking habits, pulmonary function tests, and energy-protein status were assessed; serum concentrations of retinyl esters, retinol, retinol binding protein, and transthyretin and relative dose responses were measured. In addition, 12 male smokers aged 45-61 y with mild COPD were randomly assigned to two groups for a longitudinal study: six subjects consumed vitamin A (1000 RE/d; COPD- vitamin A) and six subjects received placebo for 30 d. Lowered serum retinol concentrations were found in the COPD-moderate-severe and COPD-moderate- severe+ex groups. Measurements of vitamin A status in healthy smokers and in COPD-mild patients were not different from those in healthy nonsmokers. The improvement of pulmonary function test results after vitamin A supplementation [mean increase for 1-s forced expiratory volume (FEV1) = 22.9% in the COPD-vitamin A group] may support the assumption of a local (respiratory) vitamin A deficiency in patients with this disease. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.format.extent | 928-934 | - |
dc.language.iso | eng | - |
dc.source | Scopus | - |
dc.subject | chronic obstructive pulmonary disease | - |
dc.subject | pulmonary function tests | - |
dc.subject | retinol circulating complex | - |
dc.subject | Vitamin A status assessment | - |
dc.subject | acute phase protein | - |
dc.subject | albumin | - |
dc.subject | alpha carotene | - |
dc.subject | beta carotene | - |
dc.subject | c reactive protein | - |
dc.subject | ceruloplasmin | - |
dc.subject | placebo | - |
dc.subject | prealbumin | - |
dc.subject | retinol binding protein | - |
dc.subject | retinol ester | - |
dc.subject | retinol palmitate | - |
dc.subject | airway obstruction | - |
dc.subject | chronic obstructive lung disease | - |
dc.subject | cigarette smoking | - |
dc.subject | clinical protocol | - |
dc.subject | clinical trial | - |
dc.subject | controlled clinical trial | - |
dc.subject | controlled study | - |
dc.subject | diet supplementation | - |
dc.subject | disease severity | - |
dc.subject | forced expiratory volume | - |
dc.subject | lung function test | - |
dc.subject | nutritional status | - |
dc.subject | oral drug administration | - |
dc.subject | randomized controlled trial | - |
dc.subject | retinol deficiency | - |
dc.subject | vitamin blood level | - |
dc.subject | Analysis of Variance | - |
dc.subject | Carotenoids | - |
dc.subject | Cross-Sectional Studies | - |
dc.subject | Diet | - |
dc.subject | Intestinal Absorption | - |
dc.subject | Liver | - |
dc.subject | Longitudinal Studies | - |
dc.subject | Lung | - |
dc.subject | Lung Diseases, Obstructive | - |
dc.subject | Middle Aged | - |
dc.subject | Nutritional Status | - |
dc.subject | Respiratory Function Tests | - |
dc.subject | Smoking | - |
dc.subject | Vitamin A | - |
dc.subject | Vitamin A Deficiency | - |
dc.title | Assessment of vitamin A status in chronic obstructive pulmonary disease patients and healthy smokers | en |
dc.type | outro | - |
dc.contributor.institution | Universidade de São Paulo (USP) | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Department of Internal Medicine Faculty of Medicine of Botucatu, 18618-000, Botucatu, SP | - |
dc.description.affiliationUnesp | Department of Internal Medicine, Faculty of Medicine of Botucatu UNESP, Brazil. | - |
dc.identifier.wos | WOS:A1996VU81400016 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | American Journal of Clinical Nutrition | - |
dc.identifier.scopus | 2-s2.0-0029850635 | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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