Please use this identifier to cite or link to this item:
http://acervodigital.unesp.br/handle/11449/64880
- Title:
- Assessment of vitamin A status in chronic obstructive pulmonary disease patients and healthy smokers
- Universidade de São Paulo (USP)
- Universidade Estadual Paulista (UNESP)
- 0002-9165
- Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
- The relation between vitamin A status and the degree of lung airway obstruction was examined in a cross-sectional study of 36 male subjects aged 43-74 y who were assigned to five groups as follows: healthy nonsmokers (n = 7), healthy smokers (n = 7), mild chronic obstructive pulmonary disease (COPD-mild) patients (n = 9), COPD-moderate-severe patients (n = 7), and COPD-moderate-severe patients with exacerbation (+ex; n = 6). Smoking habits, pulmonary function tests, and energy-protein status were assessed; serum concentrations of retinyl esters, retinol, retinol binding protein, and transthyretin and relative dose responses were measured. In addition, 12 male smokers aged 45-61 y with mild COPD were randomly assigned to two groups for a longitudinal study: six subjects consumed vitamin A (1000 RE/d; COPD- vitamin A) and six subjects received placebo for 30 d. Lowered serum retinol concentrations were found in the COPD-moderate-severe and COPD-moderate- severe+ex groups. Measurements of vitamin A status in healthy smokers and in COPD-mild patients were not different from those in healthy nonsmokers. The improvement of pulmonary function test results after vitamin A supplementation [mean increase for 1-s forced expiratory volume (FEV1) = 22.9% in the COPD-vitamin A group] may support the assumption of a local (respiratory) vitamin A deficiency in patients with this disease.
- 1-Dec-1996
- American Journal of Clinical Nutrition, v. 64, n. 6, p. 928-934, 1996.
- 928-934
- chronic obstructive pulmonary disease
- pulmonary function tests
- retinol circulating complex
- Vitamin A status assessment
- acute phase protein
- albumin
- alpha carotene
- beta carotene
- c reactive protein
- ceruloplasmin
- placebo
- prealbumin
- retinol binding protein
- retinol ester
- retinol palmitate
- airway obstruction
- chronic obstructive lung disease
- cigarette smoking
- clinical protocol
- clinical trial
- controlled clinical trial
- controlled study
- diet supplementation
- disease severity
- forced expiratory volume
- lung function test
- nutritional status
- oral drug administration
- randomized controlled trial
- retinol deficiency
- vitamin blood level
- Analysis of Variance
- Carotenoids
- Cross-Sectional Studies
- Diet
- Intestinal Absorption
- Liver
- Longitudinal Studies
- Lung
- Lung Diseases, Obstructive
- Middle Aged
- Nutritional Status
- Respiratory Function Tests
- Smoking
- Vitamin A
- Vitamin A Deficiency
- http://ajcn.nutrition.org/content/64/6/928.abstract
- Acesso restrito
- outro
- http://repositorio.unesp.br/handle/11449/64880
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.