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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/64893
Title: 
Can trifluoperazine protect mitochondria against reactive oxygen species-induced damage?
Author(s): 
Institution: 
  • Universidade Estadual Paulista (UNESP)
  • Universidade de Brasília (UnB)
ISSN: 
0378-7966
Abstract: 
Trifluoperazine (TFP) (35 μM) prevents mitochondrial transmembrane potential (ΔΨ) collapse and swelling induced by 10 μM Ca2+ plus oxyradicals generated from δ-aminolevulinic acid autoxidation. In contrast with EGTA, TFP cannot restore the totally collapsed ΔΨ. So, TFP might not remove Ca2+ from its 'harmful site', but could impair the ROS-driven cross-linking between membrane -SH proteins. Our data are correlated with the protective uses of TFP against oxidative processes promoted by oxyradicals plus Ca2+.
Issue Date: 
1-Dec-1996
Citation: 
European Journal of Drug Metabolism and Pharmacokinetics, v. 21, n. 4, p. 281-284, 1996.
Time Duration: 
281-284
Keywords: 
  • Ca2+
  • Mitochondria
  • Oxidative stress
  • Reactive oxygen species
  • Trifluoperazine
  • reactive oxygen metabolite
  • trifluoperazine
  • animal tissue
  • liver disease
  • liver mitochondrion
  • membrane potential
  • mitochondrial membrane
  • mitochondrion swelling
  • nonhuman
  • oxidative stress
  • rat
  • Aminolevulinic Acid
  • Animals
  • Calcium
  • Membrane Potentials
  • Mitochondria, Liver
  • Oxidation-Reduction
  • Permeability
  • Rats
  • Rats, Wistar
  • Reactive Oxygen Species
Source: 
http://dx.doi.org/10.1007/BF03189728
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/64893
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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