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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/64893
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dc.contributor.authorDe Souza Pereira, R.-
dc.contributor.authorHermes-Lima, M.-
dc.date.accessioned2014-05-27T11:18:08Z-
dc.date.accessioned2016-10-25T18:14:04Z-
dc.date.available2014-05-27T11:18:08Z-
dc.date.available2016-10-25T18:14:04Z-
dc.date.issued1996-12-01-
dc.identifierhttp://dx.doi.org/10.1007/BF03189728-
dc.identifier.citationEuropean Journal of Drug Metabolism and Pharmacokinetics, v. 21, n. 4, p. 281-284, 1996.-
dc.identifier.issn0378-7966-
dc.identifier.urihttp://hdl.handle.net/11449/64893-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/64893-
dc.description.abstractTrifluoperazine (TFP) (35 μM) prevents mitochondrial transmembrane potential (ΔΨ) collapse and swelling induced by 10 μM Ca2+ plus oxyradicals generated from δ-aminolevulinic acid autoxidation. In contrast with EGTA, TFP cannot restore the totally collapsed ΔΨ. So, TFP might not remove Ca2+ from its 'harmful site', but could impair the ROS-driven cross-linking between membrane -SH proteins. Our data are correlated with the protective uses of TFP against oxidative processes promoted by oxyradicals plus Ca2+.en
dc.format.extent281-284-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectCa2+-
dc.subjectMitochondria-
dc.subjectOxidative stress-
dc.subjectReactive oxygen species-
dc.subjectTrifluoperazine-
dc.subjectreactive oxygen metabolite-
dc.subjecttrifluoperazine-
dc.subjectanimal tissue-
dc.subjectliver disease-
dc.subjectliver mitochondrion-
dc.subjectmembrane potential-
dc.subjectmitochondrial membrane-
dc.subjectmitochondrion swelling-
dc.subjectnonhuman-
dc.subjectoxidative stress-
dc.subjectrat-
dc.subjectAminolevulinic Acid-
dc.subjectAnimals-
dc.subjectCalcium-
dc.subjectMembrane Potentials-
dc.subjectMitochondria, Liver-
dc.subjectOxidation-Reduction-
dc.subjectPermeability-
dc.subjectRats-
dc.subjectRats, Wistar-
dc.subjectReactive Oxygen Species-
dc.titleCan trifluoperazine protect mitochondria against reactive oxygen species-induced damage?en
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de Brasília (UnB)-
dc.description.affiliationDepartment of Biochemistry Instituto de Química Universidade Estadual Paulista, Araraquara, São Paulo-
dc.description.affiliationOxygen Radicals Research Group Departamento de Biologia Celular Universidade de Brasília, Brasília, DF-
dc.description.affiliationDepartment of Biochemistry Institute de Química Universidade Estadual Paulista, CP.355, CEP 14801-970, Araraquara, SP-
dc.description.affiliationUnespDepartment of Biochemistry Instituto de Química Universidade Estadual Paulista, Araraquara, São Paulo-
dc.description.affiliationUnespDepartment of Biochemistry Institute de Química Universidade Estadual Paulista, CP.355, CEP 14801-970, Araraquara, SP-
dc.identifier.doi10.1007/BF03189728-
dc.identifier.wosWOS:A1996WM98400001-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofEuropean Journal of Drug Metabolism and Pharmacokinetics-
dc.identifier.scopus2-s2.0-0030498766-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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