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http://acervodigital.unesp.br/handle/11449/64893- Título:
- Can trifluoperazine protect mitochondria against reactive oxygen species-induced damage?
- Universidade Estadual Paulista (UNESP)
- Universidade de Brasília (UnB)
- 0378-7966
- Trifluoperazine (TFP) (35 μM) prevents mitochondrial transmembrane potential (ΔΨ) collapse and swelling induced by 10 μM Ca2+ plus oxyradicals generated from δ-aminolevulinic acid autoxidation. In contrast with EGTA, TFP cannot restore the totally collapsed ΔΨ. So, TFP might not remove Ca2+ from its 'harmful site', but could impair the ROS-driven cross-linking between membrane -SH proteins. Our data are correlated with the protective uses of TFP against oxidative processes promoted by oxyradicals plus Ca2+.
- 1-Dez-1996
- European Journal of Drug Metabolism and Pharmacokinetics, v. 21, n. 4, p. 281-284, 1996.
- 281-284
- Ca2+
- Mitochondria
- Oxidative stress
- Reactive oxygen species
- Trifluoperazine
- reactive oxygen metabolite
- trifluoperazine
- animal tissue
- liver disease
- liver mitochondrion
- membrane potential
- mitochondrial membrane
- mitochondrion swelling
- nonhuman
- oxidative stress
- rat
- Aminolevulinic Acid
- Animals
- Calcium
- Membrane Potentials
- Mitochondria, Liver
- Oxidation-Reduction
- Permeability
- Rats
- Rats, Wistar
- Reactive Oxygen Species
- http://dx.doi.org/10.1007/BF03189728
- Acesso restrito
- outro
- http://repositorio.unesp.br/handle/11449/64893
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