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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/64904
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dc.contributor.authorSaraiva, E. C O-
dc.contributor.authorAltemani, A.-
dc.contributor.authorFranco, M. F.-
dc.contributor.authorUnterkircher, C. S.-
dc.contributor.authorCamargo, Z. P.-
dc.date.accessioned2014-05-27T11:18:08Z-
dc.date.accessioned2016-10-25T18:14:05Z-
dc.date.available2014-05-27T11:18:08Z-
dc.date.available2016-10-25T18:14:05Z-
dc.date.issued1996-12-01-
dc.identifierhttp://dx.doi.org/10.1080/02681219680000261-
dc.identifier.citationJournal of Medical and Veterinary Mycology, v. 34, n. 3, p. 155-161, 1996.-
dc.identifier.issn0268-1218-
dc.identifier.urihttp://hdl.handle.net/11449/64904-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/64904-
dc.description.abstractA purified glycoprotein of 43 000 daltons from Paracoccidioides brasiliensis (gp43) was tested as paracoccidioidin in delayed-type hypersensitivity (DTH) tests in both experimental animals (guinea pig and mice) and patients with paracoccidioidomycosis (PCM). The gp43 paracoccidioidin was compared with the traditional Fava Netto antigen (AgFN). In guinea pigs, the intradermal injection of 2 μg of gp43 showed a similar response to those obtained with AgFN, showing in histological sections a population of lymphoid cells that participate in DTH. In mice, gp43 at a dose of 3.75μg showed positive DTH response. The use of gp43 as paracoccidioidin in humans showed that this molecule can be used to evaluate the DTH response in patients with PCM. Of 25 PCM patients studied, 48% were positive to gp43 while only 28% were positive to AgFN; 12 PCM patients were completely anergic to both antigens. Considering only those 13 PCM patients who were responsive to gp43 and/or to AgFN, 92.3% reacted against gp43 and 53.8% reacted against AgFN (P < 0.05). Gp43 skin test responses (13.67 ± 9.56 mm) were significantly larger than those obtained with AgFN (8.43 ±3.69 mm). Immunohistochemical study of the human skin showed a perivascular inflammatory response constituted predominantly by T lymphocytes, macrophages and polymorphonuclear leukocytes. © 1996 ISHAM.en
dc.format.extent155-161-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectGp43-
dc.subjectP. Brasiliensis-
dc.subjectParacoccidioidin-
dc.subjectParacoccidioidomycosis-
dc.subjectfungus antigen-
dc.subjectfungal protein-
dc.subjectparacoccidioidin-
dc.subjectanimal experiment-
dc.subjectcontrolled study-
dc.subjectdelayed hypersensitivity-
dc.subjectguinea pig-
dc.subjecthuman-
dc.subjecthuman tissue-
dc.subjectimmune response-
dc.subjectimmunohistochemistry-
dc.subjectinflammation-
dc.subjectmouse-
dc.subjectnonhuman-
dc.subjectparacoccidioides brasiliensis-
dc.subjectserum-
dc.subjectskin-
dc.subjectsouth american blastomycosis-
dc.subjectadult-
dc.subjectanimal-
dc.subjectchemically induced disorder-
dc.subjectcomparative study-
dc.subjectimmunology-
dc.subjectmale-
dc.subjectmicrobiology-
dc.subjectParacoccidioides-
dc.subjectskin test-
dc.subjectSouth American blastomycosis-
dc.subjectAdult-
dc.subjectAnimals-
dc.subjectFungal Proteins-
dc.subjectGuinea Pigs-
dc.subjectHumans-
dc.subjectHypersensitivity, Delayed-
dc.subjectMale-
dc.subjectMice-
dc.subjectSkin Tests-
dc.titleParacoccidioides brasiliensis-gp43 used as paracoccidioidinen
dc.typeoutro-
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniversidade Federal de São Paulo Escola Paulista de Medidna Disciplina de Biologia Celular, Rua Botucatu, 862/8, 04023-062, São Paulo, SP-
dc.description.affiliationDepartamento de Anatomia Patológica UNICAMP, Campinas, São Paulo, SP-
dc.description.affiliationDepartamento de Anatomia Patológica Faculdade de Medidna de Botucatu UNESP, Botucatu, SP-
dc.description.affiliationDepartamento de Patológia Faculdade de Odontologia de São José Dos Campos UNESP, SP-
dc.description.affiliationUnespDepartamento de Anatomia Patológica Faculdade de Medidna de Botucatu UNESP, Botucatu, SP-
dc.description.affiliationUnespDepartamento de Patológia Faculdade de Odontologia de São José Dos Campos UNESP, SP-
dc.identifier.doi10.1080/02681219680000261-
dc.identifier.wosWOS:A1996UN54900001-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Medical and Veterinary Mycology-
dc.identifier.scopus2-s2.0-0029661850-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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