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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/6508
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dc.contributor.authorSantos, Lucinéia dos-
dc.contributor.authorAndrade, Telma Gonçalves Carneiro Spera de-
dc.contributor.authorGraeff, Frederico G.-
dc.date.accessioned2014-05-20T13:22:13Z-
dc.date.accessioned2016-10-25T16:43:30Z-
dc.date.available2014-05-20T13:22:13Z-
dc.date.available2016-10-25T16:43:30Z-
dc.date.issued2010-05-01-
dc.identifierhttp://dx.doi.org/10.1177/0269881109106954-
dc.identifier.citationJournal of Psychopharmacology. London: Sage Publications Ltd, v. 24, n. 5, p. 725-731, 2010.-
dc.identifier.issn0269-8811-
dc.identifier.urihttp://hdl.handle.net/11449/6508-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/6508-
dc.description.abstractThe present work aimed to evaluate the effects of social separation for 14 days (chronic stress) and of withdrawal from a 14-day treatment with diazepam (acute stress) on the exploratory behaviour of male rats in the elevated plus-maze and on serotonin (5-hydroxytryptamine) turnover in different brain structures. Social separation had an anxiogenic effect, evidenced by fewer entries into, and less time spent on the open arms of the elevated plus-maze. Separation also selectively increased 5-hydroxytryptamine turnover in the hippocampus and median raphe nucleus. Diazepam withdrawal had a similar anxiogenic effect in grouped animals and increased 5-hydroxytryptamine turnover in the same brain structures. Chronic treatment with imipramine during the 14 days of separation prevented the behavioural and neurochemical changes caused by social separation. It is suggested that the increase in anxiety determined by both acute and chronic stress is mediated by the activation of the median raphe nucleus-hippocampal 5-hydroxytryptamine pathway.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipFundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP (FAEPA)-
dc.format.extent725-731-
dc.language.isoeng-
dc.publisherSage Publications Ltd-
dc.sourceWeb of Science-
dc.subjectsocial separationen
dc.subjectanxietyen
dc.subjectelevated plus-mazeen
dc.subjectserotoninen
dc.subjectdiazepam withdrawalen
dc.subjectimipramineen
dc.titleSocial separation and diazepam withdrawal increase anxiety in the elevated plus-maze and serotonin turnover in the median raphe and hippocampusen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.description.affiliationSão Paulo State Univ, Dept Biol Sci, BR-19806900 São Paulo, Brazil-
dc.description.affiliationSão Paulo State Univ, Physiol Lab, BR-19806900 São Paulo, Brazil-
dc.description.affiliationUniv São Paulo, Dept Neurosci & Behav Sci, Fac Med Ribeirao Preto, São Paulo, Brazil-
dc.description.affiliationUnespSão Paulo State Univ, Dept Biol Sci, BR-19806900 São Paulo, Brazil-
dc.description.affiliationUnespSão Paulo State Univ, Physiol Lab, BR-19806900 São Paulo, Brazil-
dc.identifier.doi10.1177/0269881109106954-
dc.identifier.wosWOS:000277324600012-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Psychopharmacology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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