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DC Field | Value | Language |
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dc.contributor.author | Santos, Lucinéia dos | - |
dc.contributor.author | Andrade, Telma Gonçalves Carneiro Spera de | - |
dc.contributor.author | Graeff, Frederico G. | - |
dc.date.accessioned | 2014-05-20T13:22:13Z | - |
dc.date.accessioned | 2016-10-25T16:43:30Z | - |
dc.date.available | 2014-05-20T13:22:13Z | - |
dc.date.available | 2016-10-25T16:43:30Z | - |
dc.date.issued | 2010-05-01 | - |
dc.identifier | http://dx.doi.org/10.1177/0269881109106954 | - |
dc.identifier.citation | Journal of Psychopharmacology. London: Sage Publications Ltd, v. 24, n. 5, p. 725-731, 2010. | - |
dc.identifier.issn | 0269-8811 | - |
dc.identifier.uri | http://hdl.handle.net/11449/6508 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/6508 | - |
dc.description.abstract | The present work aimed to evaluate the effects of social separation for 14 days (chronic stress) and of withdrawal from a 14-day treatment with diazepam (acute stress) on the exploratory behaviour of male rats in the elevated plus-maze and on serotonin (5-hydroxytryptamine) turnover in different brain structures. Social separation had an anxiogenic effect, evidenced by fewer entries into, and less time spent on the open arms of the elevated plus-maze. Separation also selectively increased 5-hydroxytryptamine turnover in the hippocampus and median raphe nucleus. Diazepam withdrawal had a similar anxiogenic effect in grouped animals and increased 5-hydroxytryptamine turnover in the same brain structures. Chronic treatment with imipramine during the 14 days of separation prevented the behavioural and neurochemical changes caused by social separation. It is suggested that the increase in anxiety determined by both acute and chronic stress is mediated by the activation of the median raphe nucleus-hippocampal 5-hydroxytryptamine pathway. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
dc.description.sponsorship | Fundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP (FAEPA) | - |
dc.format.extent | 725-731 | - |
dc.language.iso | eng | - |
dc.publisher | Sage Publications Ltd | - |
dc.source | Web of Science | - |
dc.subject | social separation | en |
dc.subject | anxiety | en |
dc.subject | elevated plus-maze | en |
dc.subject | serotonin | en |
dc.subject | diazepam withdrawal | en |
dc.subject | imipramine | en |
dc.title | Social separation and diazepam withdrawal increase anxiety in the elevated plus-maze and serotonin turnover in the median raphe and hippocampus | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Universidade de São Paulo (USP) | - |
dc.description.affiliation | São Paulo State Univ, Dept Biol Sci, BR-19806900 São Paulo, Brazil | - |
dc.description.affiliation | São Paulo State Univ, Physiol Lab, BR-19806900 São Paulo, Brazil | - |
dc.description.affiliation | Univ São Paulo, Dept Neurosci & Behav Sci, Fac Med Ribeirao Preto, São Paulo, Brazil | - |
dc.description.affiliationUnesp | São Paulo State Univ, Dept Biol Sci, BR-19806900 São Paulo, Brazil | - |
dc.description.affiliationUnesp | São Paulo State Univ, Physiol Lab, BR-19806900 São Paulo, Brazil | - |
dc.identifier.doi | 10.1177/0269881109106954 | - |
dc.identifier.wos | WOS:000277324600012 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Journal of Psychopharmacology | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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