You are in the accessibility menu

Please use this identifier to cite or link to this item:
Free radical production by azomethine H: Effects on pancreatic and hepatic tissues
Universidade Estadual Paulista (UNESP)
The antimalarial properties of azomethine H represent the basis for its use as a chemotherapeutic agent. This work was carried out in order to verify the biological side effects of azomethine H and to clarify the contribution of reactive oxygen species (ROS) in this process. It was shown that azomethine H increased serum activities of amylase, alanine transaminase (ALT) and the TEARS concentrations, in rats. No changes were observed in glutathione peroxidase and catalase activities. The drug-induced tissue damage might be due to superoxide radicals (O-2(.-)), since Cu-Zn superoxide dismutase activities were increased by azomethine I-I treatment. This study allows tentative conclusions to be drawn regarding which reactive oxygen metabolites play a role in azomethine H activity. We concluded that (O-2(.-)) maybe produced as a mediator of azomethine H action.
Issue Date: 
Free Radical Research, v. 26, n. 4, p. 319-324, 1997.
Time Duration: 
  • Azomethine H
  • Cu-Zn superoxide dismutase
  • Glutathione peroxidase
  • Superoxide radical
  • Toxicity
  • alanine aminotransferase
  • amylase
  • antimalarial agent
  • azomethine h
  • catalase
  • copper zinc superoxide dismutase
  • free radical
  • glutathione peroxidase
  • reactive oxygen metabolite
  • superoxide
  • thiobarbituric acid reactive substance
  • unclassified drug
  • alanine aminotransferase blood level
  • amylase blood level
  • animal experiment
  • animal tissue
  • controlled study
  • dose response
  • enzyme activity
  • intraperitoneal drug administration
  • male
  • nonhuman
  • rat
  • tissue injury
  • Alanine Transaminase
  • Amylases
  • Animals
  • Antimalarials
  • Catalase
  • Dose-Response Relationship, Drug
  • Free Radicals
  • Glutathione Peroxidase
  • Liver
  • Male
  • Naphthalenesulfonates
  • Pancreas
  • Rats
  • Rats, Wistar
  • Reactive Oxygen Species
  • Superoxide Dismutase
  • Superoxides
  • Thiobarbituric Acid Reactive Substances
  • Thiosemicarbazones
  • Animalia
Access Rights: 
Acesso restrito
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.