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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/65129
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dc.contributor.authorNovelli, E. L B-
dc.contributor.authorSilva, A. M M-
dc.contributor.authorMonteiro, J. P.-
dc.contributor.authorSacomani, L. B.-
dc.contributor.authorNovellif, J. L V B-
dc.date.accessioned2014-05-27T11:18:14Z-
dc.date.accessioned2016-10-25T18:14:30Z-
dc.date.available2014-05-27T11:18:14Z-
dc.date.available2016-10-25T18:14:30Z-
dc.date.issued1997-06-25-
dc.identifierhttp://dx.doi.org/10.3109/10715769709097811-
dc.identifier.citationFree Radical Research, v. 26, n. 4, p. 319-324, 1997.-
dc.identifier.issn1071-5762-
dc.identifier.urihttp://hdl.handle.net/11449/65129-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/65129-
dc.description.abstractThe antimalarial properties of azomethine H represent the basis for its use as a chemotherapeutic agent. This work was carried out in order to verify the biological side effects of azomethine H and to clarify the contribution of reactive oxygen species (ROS) in this process. It was shown that azomethine H increased serum activities of amylase, alanine transaminase (ALT) and the TEARS concentrations, in rats. No changes were observed in glutathione peroxidase and catalase activities. The drug-induced tissue damage might be due to superoxide radicals (O-2(.-)), since Cu-Zn superoxide dismutase activities were increased by azomethine I-I treatment. This study allows tentative conclusions to be drawn regarding which reactive oxygen metabolites play a role in azomethine H activity. We concluded that (O-2(.-)) maybe produced as a mediator of azomethine H action.-
dc.format.extent319-324-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectAzomethine H-
dc.subjectCu-Zn superoxide dismutase-
dc.subjectGlutathione peroxidase-
dc.subjectSuperoxide radical-
dc.subjectToxicity-
dc.subjectalanine aminotransferase-
dc.subjectamylase-
dc.subjectantimalarial agent-
dc.subjectazomethine h-
dc.subjectcatalase-
dc.subjectcopper zinc superoxide dismutase-
dc.subjectfree radical-
dc.subjectglutathione peroxidase-
dc.subjectreactive oxygen metabolite-
dc.subjectsuperoxide-
dc.subjectthiobarbituric acid reactive substance-
dc.subjectunclassified drug-
dc.subjectalanine aminotransferase blood level-
dc.subjectamylase blood level-
dc.subjectanimal experiment-
dc.subjectanimal tissue-
dc.subjectcontrolled study-
dc.subjectdose response-
dc.subjectenzyme activity-
dc.subjectintraperitoneal drug administration-
dc.subjectmale-
dc.subjectnonhuman-
dc.subjectrat-
dc.subjecttissue injury-
dc.subjectAlanine Transaminase-
dc.subjectAmylases-
dc.subjectAnimals-
dc.subjectAntimalarials-
dc.subjectCatalase-
dc.subjectDose-Response Relationship, Drug-
dc.subjectFree Radicals-
dc.subjectGlutathione Peroxidase-
dc.subjectLiver-
dc.subjectMale-
dc.subjectNaphthalenesulfonates-
dc.subjectPancreas-
dc.subjectRats-
dc.subjectRats, Wistar-
dc.subjectReactive Oxygen Species-
dc.subjectSuperoxide Dismutase-
dc.subjectSuperoxides-
dc.subjectThiobarbituric Acid Reactive Substances-
dc.subjectThiosemicarbazones-
dc.subjectAnimalia-
dc.titleFree radical production by azomethine H: Effects on pancreatic and hepatic tissuesen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDept. of Chemistry and Biochemistry I.B. University Estadual Paulista, 18618-000, Botucatu, São Paulo-
dc.description.affiliationFaculty of Medicine University Estadual Paulista UNESP, 18618-000, Botucatu, São Paulo-
dc.description.affiliationUnespFaculty of Medicine University Estadual Paulista UNESP, 18618-000, Botucatu, São Paulo-
dc.identifier.doi10.3109/10715769709097811-
dc.identifier.wosWOS:A1997WY52200004-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofFree Radical Research-
dc.identifier.scopus2-s2.0-0030926689-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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