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DC Field | Value | Language |
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dc.contributor.author | Novelli, E. L B | - |
dc.contributor.author | Silva, A. M M | - |
dc.contributor.author | Monteiro, J. P. | - |
dc.contributor.author | Sacomani, L. B. | - |
dc.contributor.author | Novellif, J. L V B | - |
dc.date.accessioned | 2014-05-27T11:18:14Z | - |
dc.date.accessioned | 2016-10-25T18:14:30Z | - |
dc.date.available | 2014-05-27T11:18:14Z | - |
dc.date.available | 2016-10-25T18:14:30Z | - |
dc.date.issued | 1997-06-25 | - |
dc.identifier | http://dx.doi.org/10.3109/10715769709097811 | - |
dc.identifier.citation | Free Radical Research, v. 26, n. 4, p. 319-324, 1997. | - |
dc.identifier.issn | 1071-5762 | - |
dc.identifier.uri | http://hdl.handle.net/11449/65129 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/65129 | - |
dc.description.abstract | The antimalarial properties of azomethine H represent the basis for its use as a chemotherapeutic agent. This work was carried out in order to verify the biological side effects of azomethine H and to clarify the contribution of reactive oxygen species (ROS) in this process. It was shown that azomethine H increased serum activities of amylase, alanine transaminase (ALT) and the TEARS concentrations, in rats. No changes were observed in glutathione peroxidase and catalase activities. The drug-induced tissue damage might be due to superoxide radicals (O-2(.-)), since Cu-Zn superoxide dismutase activities were increased by azomethine I-I treatment. This study allows tentative conclusions to be drawn regarding which reactive oxygen metabolites play a role in azomethine H activity. We concluded that (O-2(.-)) maybe produced as a mediator of azomethine H action. | - |
dc.format.extent | 319-324 | - |
dc.language.iso | eng | - |
dc.source | Scopus | - |
dc.subject | Azomethine H | - |
dc.subject | Cu-Zn superoxide dismutase | - |
dc.subject | Glutathione peroxidase | - |
dc.subject | Superoxide radical | - |
dc.subject | Toxicity | - |
dc.subject | alanine aminotransferase | - |
dc.subject | amylase | - |
dc.subject | antimalarial agent | - |
dc.subject | azomethine h | - |
dc.subject | catalase | - |
dc.subject | copper zinc superoxide dismutase | - |
dc.subject | free radical | - |
dc.subject | glutathione peroxidase | - |
dc.subject | reactive oxygen metabolite | - |
dc.subject | superoxide | - |
dc.subject | thiobarbituric acid reactive substance | - |
dc.subject | unclassified drug | - |
dc.subject | alanine aminotransferase blood level | - |
dc.subject | amylase blood level | - |
dc.subject | animal experiment | - |
dc.subject | animal tissue | - |
dc.subject | controlled study | - |
dc.subject | dose response | - |
dc.subject | enzyme activity | - |
dc.subject | intraperitoneal drug administration | - |
dc.subject | male | - |
dc.subject | nonhuman | - |
dc.subject | rat | - |
dc.subject | tissue injury | - |
dc.subject | Alanine Transaminase | - |
dc.subject | Amylases | - |
dc.subject | Animals | - |
dc.subject | Antimalarials | - |
dc.subject | Catalase | - |
dc.subject | Dose-Response Relationship, Drug | - |
dc.subject | Free Radicals | - |
dc.subject | Glutathione Peroxidase | - |
dc.subject | Liver | - |
dc.subject | Male | - |
dc.subject | Naphthalenesulfonates | - |
dc.subject | Pancreas | - |
dc.subject | Rats | - |
dc.subject | Rats, Wistar | - |
dc.subject | Reactive Oxygen Species | - |
dc.subject | Superoxide Dismutase | - |
dc.subject | Superoxides | - |
dc.subject | Thiobarbituric Acid Reactive Substances | - |
dc.subject | Thiosemicarbazones | - |
dc.subject | Animalia | - |
dc.title | Free radical production by azomethine H: Effects on pancreatic and hepatic tissues | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Dept. of Chemistry and Biochemistry I.B. University Estadual Paulista, 18618-000, Botucatu, São Paulo | - |
dc.description.affiliation | Faculty of Medicine University Estadual Paulista UNESP, 18618-000, Botucatu, São Paulo | - |
dc.description.affiliationUnesp | Faculty of Medicine University Estadual Paulista UNESP, 18618-000, Botucatu, São Paulo | - |
dc.identifier.doi | 10.3109/10715769709097811 | - |
dc.identifier.wos | WOS:A1997WY52200004 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Free Radical Research | - |
dc.identifier.scopus | 2-s2.0-0030926689 | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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