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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/65148
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dc.contributor.authorNovelli, E. L B-
dc.contributor.authorRodrigues, N. L.-
dc.contributor.authorSforcin, J. M.-
dc.contributor.authorRibas, B. O.-
dc.date.accessioned2014-05-27T11:18:15Z-
dc.date.accessioned2016-10-25T18:14:32Z-
dc.date.available2014-05-27T11:18:15Z-
dc.date.available2016-10-25T18:14:32Z-
dc.date.issued1997-07-10-
dc.identifierhttp://www.ingentaconnect.com/content/tandf/utsm/1997/00000016/00000003/art00005-
dc.identifier.citationToxic Substance Mechanisms, v. 16, n. 3, p. 251-258, 1997.-
dc.identifier.issn1076-9188-
dc.identifier.urihttp://hdl.handle.net/11449/65148-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/65148-
dc.description.abstractThe role of air pollution as a health risk factor is of special interest. Numerous toxic pollutants, such as nickel, are being released to the environment as a result of combustion of fossil fuels, crude oil, and coal. Nickel in the atmosphere can be combined with other environmental pollutants, producing various nickel compounds, which have varying animal toxicity. A rat biossay validated for the identification of toxic effects of nickel revealed increased serum activities of total lactate dehydrogenase (LDH) and alanine transaminase (ALT) in rats that received intratracheal injection of Ni2+ in .09% saline solution of NiCl2. The total LDH activity was also increased in the heart, and the isoenzyme pattern showed the LDH1/LDH2 ratio elevated to greater than 1. We conclude that intratracheal administration of nickel induced cardiac and hepatic damage. The development of cardiac and hepatic damage and of increased enzymes' activities was only demonstrated when nickel had accumulated in these tissues, indicating that nickel depot is essential to its toxicity. Intratracheal administration of NiCl2 induced changes in LDH and ALT activities.en
dc.format.extent251-258-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectnickel-
dc.subjectair pollution-
dc.subjectanimal experiment-
dc.subjectcardiotoxicity-
dc.subjectheavy metal poisoning-
dc.subjectliver toxicity-
dc.subjectnonhuman-
dc.subjectrat-
dc.subjectrisk factor-
dc.subjectAnimalia-
dc.titleToxic effects of nickel exposure on heart and liver of ratsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionInstituto de Salud Carlos III-
dc.description.affiliationDepartment of Chemistry Institute de Biociências Universidade Estadual Paulista-UNESP, São Paulo-
dc.description.affiliationDepartment of Microbiology Instituto de Biociências Universidade Estadual Paulista-UNESP, São Paulo-
dc.description.affiliationDepartment of Toxicology Natl. Centre of Environmental Health Instituto de Salud Carlos III, Madrid-
dc.description.affiliationDepartamento de Química Institute de Biociências Universidade Estadual Paulista-UNESP, Caixa Postal 510, 18618-000 Botucatu, São Paulo-
dc.description.affiliationUnespDepartment of Chemistry Institute de Biociências Universidade Estadual Paulista-UNESP, São Paulo-
dc.description.affiliationUnespDepartment of Microbiology Instituto de Biociências Universidade Estadual Paulista-UNESP, São Paulo-
dc.description.affiliationUnespDepartamento de Química Institute de Biociências Universidade Estadual Paulista-UNESP, Caixa Postal 510, 18618-000 Botucatu, São Paulo-
dc.identifier.wosWOS:A1997XF28600005-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofToxic Substance Mechanisms-
dc.identifier.scopus2-s2.0-0030970703-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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