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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/65151
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dc.contributor.authorBueno, J. P.-
dc.contributor.authorMendes-Giannini, Maria José Soares-
dc.contributor.authorDel Negro, G. M. B.-
dc.contributor.authorAssis, C. M.-
dc.contributor.authorTakiguti, C. K.-
dc.contributor.authorShikanai-Yasuda, M. A.-
dc.date.accessioned2014-05-27T11:18:15Z-
dc.date.accessioned2016-10-25T18:14:32Z-
dc.date.available2014-05-27T11:18:15Z-
dc.date.available2016-10-25T18:14:32Z-
dc.date.issued1997-07-22-
dc.identifierhttp://dx.doi.org/10.1080/02681219780001161-
dc.identifier.citationJournal of Medical and Veterinary Mycology, v. 35, n. 3, p. 213-217, 1997.-
dc.identifier.issn0268-1218-
dc.identifier.issn1369-3786-
dc.identifier.issn1460-2709-
dc.identifier.urihttp://hdl.handle.net/11449/65151-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/65151-
dc.description.abstractIgG, IgM and IgA antibodies to GP43 (glycoprotein fraction of Paracoccidioides brasiliensis) were measured by ELISA in 63 samples from 23 patients with paracoccidioidomycosis before and twice after chemotherapy was started. Antibodies against P. brasiliensis were detected by indirect immunofluorescence (IF) (IgG, IgM and IgA isotypes), counterimmunoelectrophoresis (CIE) and complement fixation. Two control groups composed of 19 healthy individuals and 12 patients with other diseases (six with histoplasmosis, three with tuberculosis and three with other mycoses). The highest efficiency percentages were found with IgG and IgA- ELISA (100%), IgG-IF (96.2%), CIE (94.4%) and the lowest with CF (75.9%). Highest positive and negative predictive values (100%) were observed for IgG and IgA ELISA. IgG and IgM-ELISA antibodies are more often found in patients with acute than chronic disease (P = 0.01). Four to six months after treatment follow-up showed decreased levels of IgG and IgM-ELISA for acute cases and decreased titres of CIE for chronic cases in relation to pretreatment levels. This study suggests that IgG-ELISA anti-GP43 represents a good marker to monitor clinical response to therapy.en
dc.format.extent213-217-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectDiagnosis-
dc.subjectELISA anti-GP43-
dc.subjectP. brasiliensis-
dc.subjectParacoccidioidomycosis-
dc.subjectglycoprotein-
dc.subjectimmunoglobulin a antibody-
dc.subjectimmunoglobulin g antibody-
dc.subjectimmunoglobulin m antibody-
dc.subjectantibody response-
dc.subjectbiopsy-
dc.subjectcomplement fixation-
dc.subjectcontrolled study-
dc.subjectcounter immunoelectrophoresis-
dc.subjectenzyme linked immunosorbent assay-
dc.subjectfollow up-
dc.subjectfungus identification-
dc.subjecthistoplasma capsulatum-
dc.subjecthuman-
dc.subjectimmunofluorescence-
dc.subjectmajor clinical study-
dc.subjectparacoccidioides brasiliensis-
dc.subjectsouth american blastomycosis-
dc.subjectsputum analysis-
dc.subjectAcute Disease-
dc.subjectAntibodies, Fungal-
dc.subjectAntibody Formation-
dc.subjectAntifungal Agents-
dc.subjectChronic Disease-
dc.subjectComplement Fixation Tests-
dc.subjectCounterimmunoelectrophoresis-
dc.subjectEnzyme-Linked Immunosorbent Assay-
dc.subjectFluorescent Antibody Technique, Indirect-
dc.subjectHumans-
dc.subjectImmunoglobulin A-
dc.subjectImmunoglobulin G-
dc.subjectImmunoglobulin M-
dc.subjectReference Values-
dc.subjectAjellomyces capsulatus-
dc.subjectFungi-
dc.subjectParacoccidioides brasiliensis-
dc.subjectparacoccidioidomycosis brasiliensis-
dc.titleIgG, IgM and IgA antibody response for the diagnosis and follow-up of paracoccidioidomycosis: Comparison of counterimmunoelectrophoresis and complement fixationen
dc.typeoutro-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDepto. Doenças Infecciosas e Parasitárias da F. Medicina da USP Lab. Invest. Médica (LIM 48) H. Clínicas, F. Medicina da USP-
dc.description.affiliationLaboratório de Micologia Médico (LIM 53) H. Clínicas, F. Medicina da USP-
dc.description.affiliationLab. Processamento de Dados Biomédicos (LIM 39) H. Clínicas, F. Medicina da USP-
dc.description.affiliationF. Ciêndas Farmacêuticas UNESP-
dc.description.affiliationDepartamento de Doenças Infecciosas e Parasitárias F. Medicina USP LIM 48, Av. Dr Enéas Carvalho Aguiar, CEP 05403 902, São Paulo-
dc.description.affiliationUnespF. Ciêndas Farmacêuticas UNESP-
dc.identifier.doi10.1080/02681219780001161-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Medical and Veterinary Mycology-
dc.identifier.scopus2-s2.0-0030836629-
dc.identifier.scopus2-s2.0-79961230907-
dc.identifier.orcid0000-0002-8059-0826-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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