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- Isolation of ergosterol peroxide and its reversion to ergosterol in the pathogenic fungus Sporothrix schenckii
- Universidade Federal Fluminense (UFF)
- Universidade Federal do Rio de Janeiro (UFRJ)
- Universidade Estadual Paulista (UNESP)
- Universidade de São Paulo (USP)
- Cidade Universitária
- Ergosterol peroxide, a presumed product of the H2O2-dependent enzymatic oxidation of ergosterol, has been isolated from yeast from yeast forms of the pathogenic fungus Sporothrix schenckii. The substance, which may have a role in fungal virulence, has been characterized mainly using spectroscopic methods (1H and 13C nuclear magnetic resonance and high resolution mass spectra). The purified compound showed a molecular formula of C28H44O3, displaying characteristic features of epidioxy sterols and was reverted to ergosterol when submitted to S. schenckii enzymatic extract.
- Mycopathologia, v. 139, n. 1, p. 9-14, 1997.
- Epidioxy sterol
- Reactive oxygen species
- Sporothrix schenckii
- antineoplastic agent
- drug derivative
- ergosterol 5,8 peroxide
- isolation and purification
- nuclear magnetic resonance spectroscopy
- thin layer chromatography
- Antineoplastic Agents
- Chromatography, Thin Layer
- Magnetic Resonance Spectroscopy
- Acesso restrito
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