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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/65792
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dc.contributor.authorNogueira, Paulo J.-
dc.contributor.authorFerreira, Heloisa H. A.-
dc.contributor.authorAntunes, Edson-
dc.contributor.authorTeixeira, Nancy A.-
dc.date.accessioned2014-05-27T11:19:44Z-
dc.date.accessioned2016-10-25T18:15:45Z-
dc.date.available2014-05-27T11:19:44Z-
dc.date.available2016-10-25T18:15:45Z-
dc.date.issued1999-06-03-
dc.identifierhttp://dx.doi.org/10.1080/09629359990621-
dc.identifier.citationMediators of Inflammation, v. 8, n. 2, p. 119-122, 1999.-
dc.identifier.issn0962-9351-
dc.identifier.urihttp://hdl.handle.net/11449/65792-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/65792-
dc.description.abstractThe effects of chronic mild prenatal stress on leukocyte infiltration into the airways was investigated in rat offspring. The chronic prenatal stress consisted of transitory and variable changes in the rat's living conditions. Offspring at adult age were actively sensitized (day 0) and intratracheally challenged (day 14) with ovalbumin. Bronchoalveolar lavage was performed in the offspring at 48 h after intratracheal challenge with ovalbumin. A significant increase in total leukocyte infiltration was observed in the non-stressed offspring group and this was associated with a marked recruitment of eosinophils without a significant effect on the influx of neutrophils and mononuclear cells. In the prenatal stressed offspring, the counts of both total leukocyte and eosinophils, as well as mononuclear cells, was increased by 50% compared to the non-stressed offspring. We provide here the first experimental evidence that chronic mild unpredictable prenatal stress produces a marked increase in the allergen-induced airway inflammation in the rat offspring.en
dc.format.extent119-122-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectAsthma-
dc.subjectDevelopment-
dc.subjectEosinophils-
dc.subjectLungs-
dc.subjectPrenatal stress-
dc.subjectovalbumin-
dc.subjectanimal cell-
dc.subjectanimal experiment-
dc.subjectanimal model-
dc.subjectanimal tissue-
dc.subjectasthma-
dc.subjectcell infiltration-
dc.subjecteosinophil-
dc.subjectinflammation-
dc.subjectlung lavage-
dc.subjectmononuclear cell-
dc.subjectnonhuman-
dc.subjectprediction-
dc.subjectprenatal care-
dc.subjectpriority journal-
dc.subjectprogeny-
dc.subjectrat-
dc.subjectstress-
dc.subjectAllergens-
dc.subjectAnimals-
dc.subjectBronchial Hyperreactivity-
dc.subjectFemale-
dc.subjectFood Deprivation-
dc.subjectHousing, Animal-
dc.subjectInflammation-
dc.subjectLeukocyte Count-
dc.subjectOvalbumin-
dc.subjectPregnancy-
dc.subjectPregnancy Complications-
dc.subjectPrenatal Exposure Delayed Effects-
dc.subjectRats-
dc.subjectRats, Wistar-
dc.subjectStress, Psychological-
dc.subjectWater Deprivation-
dc.subjectAnimalia-
dc.titleChronic mild prenatal stress exacerbates the allergen-induced airway inflammation in ratsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade São Francisco (USF)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.description.affiliationDepartamento de Farmacologia Instituto de Biociências Universidade Estadual Paulista, Botucatu, SP-
dc.description.affiliationUniversidade Sao Francisco, Bragança Paulista, SP-
dc.description.affiliationDepartamento de Farmacologia Faculdade de Ciências Medicas UNICAMP, P.O. Boc 6111, 13081-970 Campinas (SP)-
dc.description.affiliationUnespDepartamento de Farmacologia Instituto de Biociências Universidade Estadual Paulista, Botucatu, SP-
dc.identifier.doi10.1080/09629359990621-
dc.identifier.wosWOS:000080836400008-
dc.rights.accessRightsAcesso aberto-
dc.identifier.file2-s2.0-0032979193.pdf-
dc.relation.ispartofMediators of Inflammation-
dc.identifier.scopus2-s2.0-0032979193-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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