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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/66022
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Campo DCValorIdioma
dc.contributor.authorOliveira, Anselmo Gomes de-
dc.contributor.authorScarpa, M. V.-
dc.date.accessioned2014-05-27T11:19:51Z-
dc.date.accessioned2016-10-25T18:16:08Z-
dc.date.available2014-05-27T11:19:51Z-
dc.date.available2016-10-25T18:16:08Z-
dc.date.issued1999-12-01-
dc.identifier.citationRevista de Ciencias Farmaceuticas, v. 20, n. 1, p. 35-47, 1999.-
dc.identifier.issn0101-3793-
dc.identifier.urihttp://hdl.handle.net/11449/66022-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/66022-
dc.description.abstractA critical revision of the literature was made regarding the stability of β-lactam antibiotics in the presence of surfactants. The factors involved in the drug decomposition were analyzed in the development of the discussion. The analysis has indicated that some organized systems obtained from surfactants can be used to control rates and mechanisms of antibiotic decomposition. These organized systems can also be used to obtain specific information about the drug reactivity in a microenvironment similar to the site of pharmacological effect.en
dc.format.extent35-47-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectβ-lactam antibiotics-
dc.subjectDrug decomposition-
dc.subjectMicelles-
dc.subjectMicroemulsions-
dc.subjectSurfactants-
dc.subjectamoxicillin-
dc.subjectampicillin-
dc.subjectbeta lactam antibiotic-
dc.subjectcefaclor-
dc.subjectcefadroxil-
dc.subjectcefalexin-
dc.subjectcefazolin-
dc.subjectcefradine-
dc.subjectcephalosporin derivative-
dc.subjectcetrimide-
dc.subjectdodecyl sulfate sodium-
dc.subjectpenicillin derivative-
dc.subjectpenicillin G-
dc.subjectpolidocanol-
dc.subjectpropicillin-
dc.subjectsurfactant-
dc.subjectdrug decomposition-
dc.subjectdrug hydrolysis-
dc.subjectdrug stability-
dc.subjectdrug structure-
dc.subjectionic strength-
dc.subjectmicelle-
dc.subjectmicroemulsion-
dc.subjectpH-
dc.subjectreview-
dc.titleEffect of micelles, microemulsions and other supramolecular aggregates on the hydrolysis of β-lactam antibioticsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDepto. de Farmacos e Medicamentos Faculdade de Ciencias Farmaceuticas UNESP, 14801-902 - Araraquara - SP-
dc.description.affiliationUnespDepto. de Farmacos e Medicamentos Faculdade de Ciencias Farmaceuticas UNESP, 14801-902 - Araraquara - SP-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofRevista de Ciencias Farmaceuticas-
dc.identifier.scopus2-s2.0-0033381749-
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