You are in the accessibility menu

Please use this identifier to cite or link to this item:
Clinical evaluation of amitriptyline for the control of chronic pain caused by temporomandibular joint disorders
  • Depto. de Protese e Periodontia
  • Universidade de São Paulo (USP)
  • Intl. Assoc. for the Study of Pain
  • Intl. Assoc. for Dental Research
  • Universidade Estadual de Campinas (UNICAMP)
  • Intl. Assoc. for Dental Researchers
  • Dental School of Piracicaba
  • Brazilian Soc. for Dental Research
  • International Biometric Society
  • Universidade Estadual Paulista (UNESP)
  • A. C. Camargo Cancer Center
Temporomandibular disorder (TMD) is characterized by a combination of symptoms affecting the temporomandibular joint and/or chewing muscles. The two most common clinical TMD symptoms are pain and dysfunction. Pain is usually caused by dysfunction, and emergency therapy has focused on controlling it. Recent investigations into TMD have led to the recommendation of antidepressants as a supporting treatment against constant neuralgic pain. The aim of this double-blind study was to verify the efficiency of antidepressants (amitriptyline) as a support in the treatment of chronic TMD pain. Twelve female volunteers presenting chronic TMD pain were divided into two groups and treated for 14 days: Group 1 with 25 mg/day of amitriptyline and Group 2 with a placebo. The intensity of pain and discomfort was evaluated daily, using a visual analog scale (VAS), over a period of seven days preceding the treatment (baseline), during the 14-day treatment, and for seven days after the treatment. The results revealed a significant reduction of pain and discomfort in Group 1 (75%) compared to Group 2 (28%) during the three weeks beginning at baseline (p< 0.01). Amitriptyline proved to be an efficient alternative treatment for chronic pain in TMD patients. Copyright © 2003 by CHROMA, Inc.
Issue Date: 
Cranio, v. 21, n. 3, p. 221-225, 2003.
Time Duration: 
  • amitriptyline
  • antidepressant agent
  • tricyclic antidepressant agent
  • analgesia
  • chronic pain
  • clinical article
  • clinical trial
  • comparative study
  • controlled clinical trial
  • controlled study
  • double blind procedure
  • drug efficacy
  • female
  • human
  • pain assessment
  • temporomandibular joint disorder
  • treatment outcome
  • visual analog scale
  • chronic disease
  • face pain
  • randomized controlled trial
  • Amitriptyline
  • Antidepressive Agents, Tricyclic
  • Chronic Disease
  • Double-Blind Method
  • Facial Pain
  • Female
  • Humans
  • Pain Measurement
  • Temporomandibular Joint Disorders
  • Treatment Outcome
Access Rights: 
Acesso restrito
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.