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Ativação de macrófagos por produtos naturais obtidos da Achillea millefolium L. (Asteraceae)
Other Titles: 
Macrophage activation by natural products from Achillea millefolium L.(Asteraceae)
Universidade Estadual Paulista (UNESP)
Plants are a valuable source of natural products for the maintenance of human health. The purpose of this paper was the study of immunologic activity of yarrow (Achillea millefolium L.), a largely used plant in popular medicine that has many different properties such as: antiinflammatory, astringent, antiseptic and antispasmodic. Macrophages stimulation was evaluated by the determination of H2O2, NO and TNF-α in supernatants of peritoneal macrophages cultures of mice in the presence of the yarrow leaves extract. The thin layer chromatography of extract was also analyzed, showing rutin. All concentrations showed a moderate release of H2O2 and the concentrations of 6, 8 and 10mg/mL had a higher release of NO. The TNF-a was produced in all concentrations, but the best result was obtained at 4mg/mL. Analyzing the results, it is suggested that the yarrow ethanolic extract can modulate the macrophages activation.
Issue Date: 
Revista de Ciencias Farmaceuticas, v. 24, n. 1, p. 61-69, 2003.
Time Duration: 
  • Achillea millefolium L.
  • Hydrogen peroxide
  • Macrophages
  • Nitric oxide
  • Tumor necrosis factor- α
  • Yarrow
  • Achillea millefolium extract
  • hydrogen peroxide
  • natural product
  • nitric oxide
  • tumor necrosis factor alpha
  • Achillea
  • animal cell
  • antiinflammatory activity
  • antispasmodic activity
  • astringent activity
  • controlled study
  • dose response
  • drug activity
  • immunoreactivity
  • macrophage activation
  • mouse
  • nonhuman
  • peritoneum macrophage
  • plant leaf
  • supernatant
  • thin layer chromatography
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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