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DC Field | Value | Language |
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dc.contributor.author | Lopes, F. C M | - |
dc.contributor.author | Moreira, Raquel Regina Duarte | - |
dc.contributor.author | Carlos, Iracilda Zeppone | - |
dc.date.accessioned | 2014-05-27T11:20:59Z | - |
dc.date.accessioned | 2016-10-25T18:19:12Z | - |
dc.date.available | 2014-05-27T11:20:59Z | - |
dc.date.available | 2016-10-25T18:19:12Z | - |
dc.date.issued | 2003-12-01 | - |
dc.identifier.citation | Revista de Ciencias Farmaceuticas, v. 24, n. 1, p. 61-69, 2003. | - |
dc.identifier.issn | 0101-3793 | - |
dc.identifier.uri | http://hdl.handle.net/11449/67565 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/67565 | - |
dc.description.abstract | Plants are a valuable source of natural products for the maintenance of human health. The purpose of this paper was the study of immunologic activity of yarrow (Achillea millefolium L.), a largely used plant in popular medicine that has many different properties such as: antiinflammatory, astringent, antiseptic and antispasmodic. Macrophages stimulation was evaluated by the determination of H2O2, NO and TNF-α in supernatants of peritoneal macrophages cultures of mice in the presence of the yarrow leaves extract. The thin layer chromatography of extract was also analyzed, showing rutin. All concentrations showed a moderate release of H2O2 and the concentrations of 6, 8 and 10mg/mL had a higher release of NO. The TNF-a was produced in all concentrations, but the best result was obtained at 4mg/mL. Analyzing the results, it is suggested that the yarrow ethanolic extract can modulate the macrophages activation. | en |
dc.format.extent | 61-69 | - |
dc.language.iso | por | - |
dc.source | Scopus | - |
dc.subject | Achillea millefolium L. | - |
dc.subject | Hydrogen peroxide | - |
dc.subject | Macrophages | - |
dc.subject | Nitric oxide | - |
dc.subject | Tumor necrosis factor- α | - |
dc.subject | Yarrow | - |
dc.subject | Achillea millefolium extract | - |
dc.subject | hydrogen peroxide | - |
dc.subject | natural product | - |
dc.subject | nitric oxide | - |
dc.subject | tumor necrosis factor alpha | - |
dc.subject | Achillea | - |
dc.subject | animal cell | - |
dc.subject | antiinflammatory activity | - |
dc.subject | antispasmodic activity | - |
dc.subject | astringent activity | - |
dc.subject | controlled study | - |
dc.subject | dose response | - |
dc.subject | drug activity | - |
dc.subject | immunoreactivity | - |
dc.subject | macrophage activation | - |
dc.subject | mouse | - |
dc.subject | nonhuman | - |
dc.subject | peritoneum macrophage | - |
dc.subject | plant leaf | - |
dc.subject | supernatant | - |
dc.subject | thin layer chromatography | - |
dc.title | Ativação de macrófagos por produtos naturais obtidos da Achillea millefolium L. (Asteraceae) | pt |
dc.title.alternative | Macrophage activation by natural products from Achillea millefolium L.(Asteraceae) | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Departamento de Analises Clinicas Faculdade de Ciencias Farmaceuticas UNESP, 14801-902-Araraquara-SP | - |
dc.description.affiliation | Depto. Principios Ativos Nat./T. Faculdade de Ciencias Farmaceuticas UNESP, 14801-902-Araraquara-SP | - |
dc.description.affiliationUnesp | Departamento de Analises Clinicas Faculdade de Ciencias Farmaceuticas UNESP, 14801-902-Araraquara-SP | - |
dc.description.affiliationUnesp | Depto. Principios Ativos Nat./T. Faculdade de Ciencias Farmaceuticas UNESP, 14801-902-Araraquara-SP | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Revista de Ciencias Farmaceuticas | - |
dc.identifier.scopus | 2-s2.0-4644256641 | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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